ADORA2A and DRD2

  • Number of citations of the paper that reports this interaction (PubMedID 12804599)
  • 28
  • Data Source:
  • HPRD (in vivo)

ADORA2A

DRD2

Description adenosine A2a receptor dopamine receptor D2
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Acne (severe) ( 24927181)
  • Caffeine consumption from coffee or tea ( 33287642)
  • Caffeine consumption from tea ( 33287642)
  • Coffee consumption (cups per day) ( 31217584)
  • Coronary artery disease ( 26343387)
  • Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975)
  • Severity of nausea and vomiting of pregnancy ( 29563502)
  • Alcohol consumption ( 31358974)
  • Alcohol consumption (drinks per week) ( 30643258 30679032)
  • Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841)
  • Alcohol use disorder ( 30940813)
  • Alcohol use disorder (consumption score) ( 33861876)
  • Alcoholic chronic pancreatitis ( 28754779)
  • Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Anxiety ( 33859377)
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • Bipolar disorder ( 33263727)
  • Body mass index ( 26426971)
  • Chronotype ( 30696823)
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
  • Depression ( 33859377)
  • General factor of neuroticism ( 30867560)
  • Inferior temporal gyrus volume ( 31530798)
  • Information processing speed ( 25869804)
  • Interferon alpha levels in systemic lupus erythematosus ( 25338677)
  • Mood instability ( 31168069)
  • Neuroticism ( 27089181 29255261)
  • Problematic alcohol use ( 32451486)
  • Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)
  • Schizophrenia ( 28991256 25056061 29483656 30285260)
  • Select biomarker traits ( 17903293)
  • Sleep duration ( 27992416)
  • Smoking cessation ( 33082346)
  • Smoking status (current vs mixed) ( 33082346)
  • Smoking status (current vs never) ( 33082346)
  • Sociability score ( 34054130)
  • Systolic blood pressure in sickle cell anemia ( 24058526)
  • Triglycerides ( 30275531)
  • Walking pace ( 33128006)
  • Worry too long after an embarrassing experience ( 34054130)
Interacting Genes 31 interacting genes: ACTN1 ACTN2 ACTN3 ACTN4 ADA BET1 CD4 CDH2 CHN1 CNR1 CYTH2 DDT DRD2 FZD3 GGT1 GGT5 GPR37 HNRNPH3 HRH3 NAMPT NECAB2 PDHB POMZP3 PPM1J RHBDD2 RHOB SLC25A39 SLC35A2 SLC4A1AP SPNS1 SYNGR1 99 interacting genes: ABCA2 ADGRB1 ADGRG1 ADORA2A APH1A ARL1 ARL6IP6 ATP6V0A2 ATP6V0C BCAP29 BCAP31 CADPS CADPS2 CALM1 CALM3 CASP1 CCKBR CCNA2 CD3E CD3G CERS1 CERS2 CHPT1 CLDND1 CLIC6 CRELD1 E2F6 EPB41 EPB41L1 FLNA GABBR1 GABBR2 GDPD2 GHITM GIPC1 GNAI2 GNAI3 GNAZ GNB5 GPC6 GPR137 GPR37 GRIA2 GRINA HRH3 IL10RA INPPL1 KBTBD6 KBTBD7 KCNJ6 KCNJ9 LPAR1 NCS1 NDUFV1 NEFM NQO2 NSF OPRM1 PAQR6 PAWR PIGG PLLP PLPPR3 PPP1R9B PSG7 RBM22 RHBDD2 RTN1 RTN3 RTN4 SERINC3 SGSH SLC15A4 SLC22A17 SLC35B1 SLC4A3 SLC6A1 SLC6A3 SMIM7 SPP1 SSTR2 SSTR5 SYNGR2 TF TMEFF2 TMEM101 TMEM11 TMEM63A TRAM1 TRPC4 TRPC5 TSPAN3 TSPAN7 TTYH1 VWA5A WFS1 WLS YIPF3 ZDHHC4
Entrez ID 135 1813
HPRD ID 00043 00539
Ensembl ID ENSG00000128271 ENSG00000149295
Uniprot IDs A8K1F6 B3KVQ4 P29274 X5DNB4 A0A024R3C5 A0A024R3I6 P14416
PDB IDs 1MMH 1UPE 2YDO 2YDV 3EML 3PWH 3QAK 3REY 3RFM 3UZA 3UZC 3VG9 3VGA 4EIY 4UG2 4UHR 5G53 5IU4 5IU7 5IU8 5IUA 5IUB 5JTB 5K2A 5K2B 5K2C 5K2D 5MZJ 5MZP 5N2R 5NLX 5NM2 5NM4 5OLG 5OLH 5OLO 5OLV 5OLZ 5OM1 5OM4 5UIG 5UVI 5VRA 5WF5 5WF6 6AQF 6GDG 6GT3 6JZH 6LPJ 6LPK 6LPL 6MH8 6PS7 6S0L 6S0Q 6WQA 6ZDR 6ZDV 1I15 5AER 6CM4 6LUQ 6VMS 7JVR
Enriched GO Terms of Interacting Partners?
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