ARHGEF19 and PAK5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ARHGEF19	PAK5
Description		Rho guanine nucleotide exchange factor 19	p21 (RAC1) activated kinase 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Actin Cytoskeleton Organization Wound Healing Regulation Of Small GTPase Mediated Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway Activation Of GTPase Activity	Regulation Of Cell Growth Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Signal Transduction Learning Memory Locomotory Behavior Cell Population Proliferation Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 33339817) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Facial morphology ( 31763980) Gamma glutamyl transferase levels ( 29403010 33339817) Initial pursuit acceleration ( 29064472) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)	Atopy ( 28927820) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		2 interacting genes: PAK5 RHOA	34 interacting genes: ARHGEF19 ARMC7 ATPAF2 BAD CARD9 CATSPER1 CCDC57 CCNG1 CDC42 CRBN CSNK1D DDX6 DNPEP EMD ENKD1 EXOSC1 FHL3 GCC1 INKA1 LENG1 LNX1 LZTS2 MYO15B NTAQ1 PDLIM7 PRPF31 PSMF1 PTPN21 RAC1 RHOJ SORBS3 TSGA10 TUBGCP4 UXT
Entrez ID		128272	57144
HPRD ID		10659	06423
Ensembl ID		ENSG00000142632	ENSG00000101349
Uniprot IDs		B4DN02 Q8IW93	B0AZM9 Q9P286
PDB IDs			2F57
Enriched GO Terms of Interacting Partners?
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