SYT2 and ORMDL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SYT2	ORMDL3
Description		synaptotagmin 2	ORMDL sphingolipid biosynthesis regulator 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Chromaffin Granule Membrane Exocytic Vesicle	Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane Secretory Granule Membrane SPOTS Complex Specific Granule Membrane
	Molecular Function	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Syntaxin Binding Clathrin Binding Inositol 1,3,4,5 Tetrakisphosphate Binding	Protein Binding
	Biological Process	Regulation Of Dopamine Secretion Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Cell Differentiation Synaptic Vesicle Endocytosis Calcium Ion-regulated Exocytosis Of Neurotransmitter Cellular Response To Calcium Ion Positive Regulation Of Dendrite Extension	Negative Regulation Of B Cell Apoptotic Process Ceramide Metabolic Process Sphingomyelin Biosynthetic Process Regulation Of Smooth Muscle Contraction Positive Regulation Of Autophagy Myelination Motor Behavior Cellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Serine C-palmitoyltransferase Activity
Pathways		Toxicity of botulinum toxin type B (botB) Neurexins and neuroligins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Sphingolipid de novo biosynthesis Neutrophil degranulation
Drugs		Botulinum Toxin Type B
Diseases
GWAS		Celiac disease ( 23936387) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383)	Adult asthma ( 30787307) Asthma ( 31959851 31619474 21150878 29273806 28461288 17611496 22561531) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737) Autoimmune traits (pleiotropy) ( 30572963) Bronchial hyperresponsiveness in asthma ( 27439200) Crohn's disease ( 18587394 28067908 21102463) Hematological parameters ( 19820697) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 28425483 23000144 21399635 20639880) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Selective IgA deficiency ( 27723758) Systemic sclerosis ( 28314753) Systemising ( 31508503) Type 1 diabetes ( 30659077 21829393 25751624 19430480) Ulcerative colitis ( 28067908 20228799 21297633) White blood cell count ( 27863252 21738480)
Interacting Genes		29 interacting genes: AQP10 BNIP2 CCDC167 CLDN4 CMTM3 FA2H FUNDC2 ITGAM KLHL3 LAT MALL MIP NAPB NRXN1 ORMDL3 PLPP4 PMP22 SLC30A8 SLC35A1 SLC35A4 STON2 SYNCRIP TF THSD7B TMEM107 TMEM229B TSPO2 VAMP4 WNK1	35 interacting genes: APP AQP6 ARL13B C10orf67 CCR7 CDC27 CERS3 COQ8A CRHR1 EBP EEF1A1 ELOVL4 ERGIC3 FAM209A GET1 GPR101 GPR152 HSD17B13 KCNK5 KRT13 LEPROTL1 LMNA LNX1 MED1 MTIF3 PTPN11 REEP2 RETREG3 RNF5 ROM1 SLC10A1 SLC35C2 SLC7A1 SYT2 TMEM237
Entrez ID		127833	94103
HPRD ID		02520	17803
Ensembl ID		ENSG00000143858	ENSG00000172057
Uniprot IDs		Q8N9I0	A0A024R1W6 Q8N138
PDB IDs			6M4N 6M4O 7CQI 7CQK 7K0M 7K0N 7K0O 7K0P 7K0Q
Enriched GO Terms of Interacting Partners?
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