CLCN3 and DECR1

		CLCN3	DECR1
Description		chloride voltage-gated channel 3	2,4-dienoyl-CoA reductase 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Endosome Membrane Vesicle Membrane Membrane Integral Component Of Membrane Secretory Granule Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Ruffle Membrane Specific Granule Intracellular Membrane-bounded Organelle Axon Terminus Phagocytic Vesicle Recycling Endosome Glutamatergic Synapse	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Catalytic Complex
	Molecular Function	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Antiporter Activity Solute:proton Antiporter Activity PDZ Domain Binding Volume-sensitive Chloride Channel Activity	2,4-dienoyl-CoA Reductase (NADPH) Activity Identical Protein Binding NADPH Binding
	Biological Process	Regulation Of PH Phagocytosis, Engulfment Adult Locomotory Behavior Synaptic Transmission, Glutamatergic Photoreceptor Cell Maintenance Negative Regulation Of Cell Volume Endosomal Lumen Acidification Synaptic Transmission, GABAergic Synaptic Vesicle Lumen Acidification Chloride Transmembrane Transport Positive Regulation Of Reactive Oxygen Species Biosynthetic Process	Fatty Acid Beta-oxidation Positive Regulation Of Cold-induced Thermogenesis
Pathways		Stimuli-sensing channels	mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
Drugs			Nicotinamide adenine dinucleotide phosphate 6-METHYL-2(PROPANE-1-SULFONYL)-2H-THIENO[3,2-D][1,2,3]DIAZABORININ-1-OL
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 28991256 25056061 29483656 30285260)	Blood protein levels ( 30072576)
Interacting Genes		17 interacting genes: ANXA10 CFTR DECR1 DNAJC5 ETFDH FZD3 GOPC GPRC5C GRIA2 HPF1 HSPB1 MED23 NEK1 PDGFB PDZK1 SLC9A3R1 VPS18	4 interacting genes: APP CLCN3 HGS MMP16
Entrez ID		1182	1666
HPRD ID		02785	01959
Ensembl ID		ENSG00000109572	ENSG00000104325
Uniprot IDs		B3KXK0 P51790	A0A024R9D7 Q16698
PDB IDs			1W6U 1W73 1W8D
Enriched GO Terms of Interacting Partners?
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