DECR1 and MMP16

		DECR1	MMP16
Description		2,4-dienoyl-CoA reductase 1	matrix metallopeptidase 16
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Catalytic Complex	Extracellular Region Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Matrix
	Molecular Function	2,4-dienoyl-CoA Reductase (NADPH) Activity Identical Protein Binding NADPH Binding	Metalloendopeptidase Activity Enzyme Activator Activity Zinc Ion Binding Metalloaminopeptidase Activity
	Biological Process	Fatty Acid Beta-oxidation Positive Regulation Of Cold-induced Thermogenesis	Skeletal System Development Endochondral Ossification Proteolysis Protein Processing Extracellular Matrix Organization Collagen Catabolic Process Chondrocyte Proliferation Embryonic Cranial Skeleton Morphogenesis Regulation Of Catalytic Activity Craniofacial Suture Morphogenesis
Pathways		mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	Activation of Matrix Metalloproteinases
Drugs		Nicotinamide adenine dinucleotide phosphate 6-METHYL-2(PROPANE-1-SULFONYL)-2H-THIENO[3,2-D][1,2,3]DIAZABORININ-1-OL	Marimastat Batimastat
Diseases
GWAS		Blood protein levels ( 30072576)	Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 31043756) Body mass index and cholesterol (psychopharmacological treatment) ( 22417934) Body shape index ( 34021172) Cerebral amyloid deposition (PET imaging) ( 26252872) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Heel bone mineral density ( 30598549) Irritable mood ( 29500382) Migraine without aura ( 23793025) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 21926974 29483656 22688191 30285260 23974872) Sweet taste perception in obesity with metabolic syndrome ( 31005965) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: APP CLCN3 HGS MMP16	5 interacting genes: DECR1 DNAAF5 KISS1 LRP1 PIP4P2
Entrez ID		1666	4325
HPRD ID		01959	03776
Ensembl ID		ENSG00000104325	ENSG00000156103
Uniprot IDs		A0A024R9D7 Q16698	P51512
PDB IDs		1W6U 1W73 1W8D	1RM8
Enriched GO Terms of Interacting Partners?
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