CLCN3 and PDGFB

		CLCN3	PDGFB
Description		chloride voltage-gated channel 3	platelet derived growth factor subunit B
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Endosome Membrane Vesicle Membrane Membrane Integral Component Of Membrane Secretory Granule Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Ruffle Membrane Specific Granule Intracellular Membrane-bounded Organelle Axon Terminus Phagocytic Vesicle Recycling Endosome Glutamatergic Synapse	Golgi Membrane Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Cell Surface Basolateral Plasma Membrane Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Antiporter Activity Solute:proton Antiporter Activity PDZ Domain Binding Volume-sensitive Chloride Channel Activity	Platelet-derived Growth Factor Receptor Binding Protein Binding Collagen Binding Growth Factor Activity Superoxide-generating NADPH Oxidase Activator Activity Chemoattractant Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Platelet-derived Growth Factor Binding Growth Factor Receptor Binding
	Biological Process	Regulation Of PH Phagocytosis, Engulfment Adult Locomotory Behavior Synaptic Transmission, Glutamatergic Photoreceptor Cell Maintenance Negative Regulation Of Cell Volume Endosomal Lumen Acidification Synaptic Transmission, GABAergic Synaptic Vesicle Lumen Acidification Chloride Transmembrane Transport Positive Regulation Of Reactive Oxygen Species Biosynthetic Process	Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Monocyte Chemotaxis Positive Regulation Of Glomerular Filtration Protein Phosphorylation Heart Development Positive Regulation Of Cell Population Proliferation Response To Wounding Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Platelet Activation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Peptidyl-serine Phosphorylation Peptidyl-tyrosine Phosphorylation Hemopoiesis Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Protein Binding Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Interleukin-18-mediated Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Paracrine Signaling Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Chemotaxis Positive Regulation Of Cell Division Cell Chemotaxis Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Cellular Response To Growth Factor Stimulus Cellular Response To Mycophenolic Acid Positive Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Glomerular Mesangial Cell Development Reactive Oxygen Species Metabolic Process Positive Regulation Of Calcium Ion Import Positive Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Metanephric Mesenchymal Cell Migration
Pathways		Stimuli-sensing channels	Platelet degranulation PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer Non-integrin membrane-ECM interactions RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs			Pegpleranib
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 28991256 25056061 29483656 30285260)	Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000)
Interacting Genes		17 interacting genes: ANXA10 CFTR DECR1 DNAJC5 ETFDH FZD3 GOPC GPRC5C GRIA2 HPF1 HSPB1 MED23 NEK1 PDGFB PDZK1 SLC9A3R1 VPS18	26 interacting genes: A2M ART1 BCCIP CLCN3 COL15A1 COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 FBXO7 HMOX1 HNRNPC HRAS HSPG2 LRP1 LYVE1 MDFI PDAP1 PDGFRA PDGFRB PIK3R1 SPARC THBS1
Entrez ID		1182	5155
HPRD ID		02785	01815
Ensembl ID		ENSG00000109572	ENSG00000100311
Uniprot IDs		B3KXK0 P51790	A0A384NYY3 P01127
PDB IDs			1PDG 3MJG 4HQU 4HQX 4QCI 6T9E
Enriched GO Terms of Interacting Partners?
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