KCTD12 and GABBR2

Number of citations of the paper that reports this interaction (PubMedID 23996491)
12

Data Source:
BioGRID (pull down)

		KCTD12	GABBR2
Description		potassium channel tetramerization domain containing 12	gamma-aminobutyric acid type B receptor subunit 2
Image
GO Annotations	Cellular Component	Presynaptic Membrane Cell Projection Postsynaptic Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane G Protein-coupled Receptor Heterodimeric Complex Neuron Projection Postsynaptic Membrane GABA Receptor Complex
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	Transmembrane Signaling Receptor Activity G Protein-coupled GABA Receptor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Protein Homooligomerization	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Neuron-glial Cell Signaling
Pathways			Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Baclofen gamma-Aminobutyric acid SGS-742 Arbaclofen Arbaclofen Placarbil
Diseases
GWAS		Incident chronic kidney disease ( 30955190) Recurrent major depressive disorder x sex interaction ( 34099189) Response to fenofibrate (triglyceride levels) ( 27002377) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Gynecologic disease (multivariate analysis) ( 31488892) High chromosomal aberration frequency (chromatid type) ( 31586183) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Response to simvastatin treatment (PCSK9 protein level change) ( 25089948) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Schizophrenia ( 30285260) Systolic blood pressure change trajectory ( 27980656)
Interacting Genes		3 interacting genes: ARAP1 GABBR2 ZNF792	16 interacting genes: ATF4 ATF5 DRD2 GABBR1 GADD45G GLP1R HTR1A KCTD12 KCTD16 NSF RFXAP SAP30 SH3GL3 SPIN1 SPTLC1 TAMALIN
Entrez ID		115207	9568
HPRD ID		11060	09552
Ensembl ID		ENSG00000178695	ENSG00000136928
Uniprot IDs		A0A140VJM4 Q96CX2	H9NIL8 O75899
PDB IDs		6M8S 6QZL	4F11 4F12 4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS 6M8R 6OCP 6UO8 6UO9 6UOA 6VJM 6W2X 6WIV 7C7Q 7C7S 7CA3 7CA5 7CUM
Enriched GO Terms of Interacting Partners?
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