KCTD12 and ARAP1

Number of citations of the paper that reports this interaction (PubMedID 21275903)
9

Data Source:
BioGRID (two hybrid)

		KCTD12	ARAP1
Description		potassium channel tetramerization domain containing 12	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
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GO Annotations	Cellular Component	Presynaptic Membrane Cell Projection Postsynaptic Membrane	Nucleoplasm Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Cytoplasmic Vesicle Golgi Cisterna Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Type 1 Angiotensin Receptor Binding Metal Ion Binding
	Biological Process	Protein Homooligomerization	Positive Regulation Of Receptor Recycling Signal Transduction Regulation Of Cell Shape Actin Filament Reorganization Involved In Cell Cycle Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Movement Positive Regulation Of Filopodium Assembly Negative Regulation Of Stress Fiber Assembly
Pathways			PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Incident chronic kidney disease ( 30955190) Recurrent major depressive disorder x sex interaction ( 34099189) Response to fenofibrate (triglyceride levels) ( 27002377) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Acute insulin response ( 28490609) Alcohol dependence symptom count ( 29460428) Alloimmunization response to red blood cell transfusion in sickle cell anemia ( 25670933) Body fat percentage and fasting glucose (pairwise) ( 33619380) Body fat percentage and type 2 diabetes (pairwise) ( 33619380) Body mass index ( 28892062 25673413) Body mass index and fasting glucose (pairwise) ( 33619380) Body mass index and type 2 diabetes (pairwise) ( 33619380) Fasting blood glucose ( 25631608 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) Fasting glucose ( 33402679 34059833) Glycated hemoglobin levels ( 28898252) Household income (MTAG) ( 31844048) Insulin-related traits (multivariate analysis) ( 32002517) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Proinsulin levels ( 21873549) Rheumatoid arthritis ( 22446963) Type 2 diabetes ( 22885922 24509480 30054458 26961502 29358691 30297969 26818947 32499647 30718926 28869590) Waist circumference ( 28552196) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		3 interacting genes: ARAP1 GABBR2 ZNF792	14 interacting genes: APP ARIH2 ARPC3 CDC42 FGFR3 INPP5D KCTD12 PSD3 RAC1 TAB1 TES TP53BP1 WAPL XRCC6
Entrez ID		115207	116985
HPRD ID		11060	09440
Ensembl ID		ENSG00000178695	ENSG00000186635
Uniprot IDs		A0A140VJM4 Q96CX2	Q96P48
PDB IDs		6M8S 6QZL	4X1V
Enriched GO Terms of Interacting Partners?
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