ARAP1

Description		ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
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GO Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Cytoplasmic Vesicle Golgi Cisterna Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Type 1 Angiotensin Receptor Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Receptor Recycling Signal Transduction Regulation Of Cell Shape Actin Filament Reorganization Involved In Cell Cycle Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Movement Positive Regulation Of Filopodium Assembly Negative Regulation Of Stress Fiber Assembly
Pathways		PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Acute insulin response ( 28490609) Alcohol dependence symptom count ( 29460428) Alloimmunization response to red blood cell transfusion in sickle cell anemia ( 25670933) Body fat percentage and fasting glucose (pairwise) ( 33619380) Body fat percentage and type 2 diabetes (pairwise) ( 33619380) Body mass index ( 28892062 25673413) Body mass index and fasting glucose (pairwise) ( 33619380) Body mass index and type 2 diabetes (pairwise) ( 33619380) Fasting blood glucose ( 25631608 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) Fasting glucose ( 33402679 34059833) Glycated hemoglobin levels ( 28898252) Household income (MTAG) ( 31844048) Insulin-related traits (multivariate analysis) ( 32002517) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Proinsulin levels ( 21873549) Rheumatoid arthritis ( 22446963) Type 2 diabetes ( 22885922 24509480 30054458 26961502 29358691 30297969 26818947 32499647 30718926 28869590) Waist circumference ( 28552196) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		14 interacting genes: APP ARIH2 ARPC3 CDC42 FGFR3 INPP5D KCTD12 PSD3 RAC1 TAB1 TES TP53BP1 WAPL XRCC6
Entrez ID		116985
HPRD ID		09440
Ensembl ID		ENSG00000186635
Uniprot IDs		Q96P48
PDB IDs		4X1V
Enriched GO Terms of Interacting Partners?
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