LENG8 and PRDM16

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LENG8	PRDM16
Description		leukocyte receptor cluster member 8	PR/SET domain 16
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytosol Aggresome Transcription Repressor Complex
	Molecular Function	Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Histone-lysine N-methyltransferase Activity Sequence-specific DNA Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K9 Specific) DNA-binding Transcription Factor Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Respiration Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Brown Fat Cell Differentiation Histone H3-K9 Methylation Heterochromatin Organization Positive Regulation Of Cold-induced Thermogenesis
Pathways			PKMTs methylate histone lysines
Drugs
Diseases
GWAS			Allergic rhinitis ( 25085501) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cardiovascular disease in type 2 diabetes ( 33350037) Cognitive decline (age-related) ( 28078323) Coronary artery disease ( 29212778) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 27618448) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Headache ( 29397368) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hypertension ( 31879980) Immature fraction of reticulocytes ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antimigraine preparations) ( 31015401) Migraine ( 27182965 23793025 21666692 27322543) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Motion sickness ( 25628336) Myocardial infarction ( 33532862) Nicotine dependence symptom count ( 25555482) Nose morphology ( 29921221) Optic disc size ( 31809533) Periventricular white matter hyperintensities ( 32517579) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) QRS duration ( 25035420) Red blood cell count ( 32888494 27863252) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 30891314) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27618448) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		49 interacting genes: ANKHD1 ARID5A ATN1 BAG3 C10orf55 CAMK2A CEP70 CFAP53 COG2 CPSF7 CYSRT1 DMRTB1 DVL3 FAM166B GSE1 HMGXB4 HNRNPM IKBKG INCA1 INTS11 KDM1A LASP1 MAGED1 MAPK1IP1L MIA3 MSX2 MYOZ3 NCBP3 NUTM2F PCID2 PER2 PRDM16 PRMT5 PRMT6 PYGO1 RHOXF2 SMARCB1 SMN1 SMYD1 SNRPA SOCS7 SUV39H1 TFG TLE5 TNIP1 TRAF4 TSG101 VGLL3 ZNF34	23 interacting genes: ACOT8 ARRB1 C5 CCDC13 CFAP206 DDX6 GLMN LENG8 LONRF1 MID2 MIPOL1 NEK6 PATJ PLK4 POLR3C RBBP4 RIOK2 RUNX1T1 TCHP TEX10 TSG101 TXLNA XPA
Entrez ID		114823	63976
HPRD ID		11226	16122
Ensembl ID		ENSG00000167615	ENSG00000142611
Uniprot IDs		A0A024R4R9 C9JMY0 Q96PV6	Q9HAZ2
PDB IDs			2N1I 6BW4
Enriched GO Terms of Interacting Partners?
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