LENG8 and MSX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LENG8	MSX2
Description		leukocyte receptor cluster member 8	msh homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Chromatin Nucleus Cytosol Nuclear Speck
	Molecular Function	Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Cardiac Conduction System Development Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Embryonic Morphogenesis Cranial Suture Morphogenesis Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways			Regulation of RUNX2 expression and activity
Drugs
Diseases
GWAS			Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alzheimer's disease ( 33074286) Blond vs. brown/black hair color ( 30531825) Chin dimples ( 27182965) Chronotype ( 30696823) Depressive symptoms (SSRI exposure interaction) ( 25649181) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Red vs. brown/black hair color ( 30531825) Resistant hypertension ( 30237584) Stroke ( 26089329)
Interacting Genes		49 interacting genes: ANKHD1 ARID5A ATN1 BAG3 C10orf55 CAMK2A CEP70 CFAP53 COG2 CPSF7 CYSRT1 DMRTB1 DVL3 FAM166B GSE1 HMGXB4 HNRNPM IKBKG INCA1 INTS11 KDM1A LASP1 MAGED1 MAPK1IP1L MIA3 MSX2 MYOZ3 NCBP3 NUTM2F PCID2 PER2 PRDM16 PRMT5 PRMT6 PYGO1 RHOXF2 SMARCB1 SMN1 SMYD1 SNRPA SOCS7 SUV39H1 TFG TLE5 TNIP1 TRAF4 TSG101 VGLL3 ZNF34	56 interacting genes: ATXN1 CCDC102B CEBPA CLIC3 DLX2 DLX5 EPHB6 FBXW2 FOXH1 GATA2 GTF2F1 GTF2F2 HOXC9 LENG8 MAGED1 MAPK1 MAPK1IP1L MAT2B MGAT5B MSX1 NAF1 NR3C1 PATZ1 PIAS2 PITX1 POLR3D POU1F1 POU2AF1 POU2F2 POU6F2 PPARG PRR13 RBPMS2 RHOXF2 ROR2 RUNX2 SMAP2 SOX5 SPEN TCF7L2 TENT5D TLE1 TLE2 TLE5 TLX3 TOLLIP TSSK3 USP54 VEZF1 XRCC5 XRCC6 YTHDF1 ZBTB17 ZC3H10 ZDHHC2 ZFHX3
Entrez ID		114823	4488
HPRD ID		11226	00421
Ensembl ID		ENSG00000167615	ENSG00000120149
Uniprot IDs		A0A024R4R9 C9JMY0 Q96PV6	P35548
PDB IDs
Enriched GO Terms of Interacting Partners?
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