FMNL2 and AP1B1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FMNL2	AP1B1
Description		formin like 2	adaptor related protein complex 1 subunit beta 1
Image
GO Annotations	Cellular Component	Cytosol	Golgi Membrane Lysosomal Membrane Golgi Apparatus Cytosol Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Small GTPase Binding Cadherin Binding Actin Filament Binding	Protein Binding Protein Kinase Binding Clathrin Binding
	Biological Process	Cytoskeleton Organization Regulation Of Cell Shape Cell Migration Regulation Of Cell Morphogenesis Cortical Actin Cytoskeleton Organization	Kidney Development Intracellular Protein Transport Determination Of Left/right Symmetry Heart Development Vesicle-mediated Transport
Pathways		RHO GTPases Activate Formins RHOC GTPase cycle CDC42 GTPase cycle	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Asthma (childhood onset) ( 27611488) Corneal astigmatism ( 30306274) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 33627673 29891935) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998 29785010 31959993 30054594 29235454) Lymphocyte counts ( 32888494) Refractive astigmatism ( 30306274) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) White blood cell count ( 32888494)	Aspartate aminotransferase levels ( 33547301) Carotid atherosclerosis in HIV infection ( 20009918) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Pancreatic cancer ( 25086665) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		13 interacting genes: AP1B1 AP2B1 APP ARL6IP6 CCDC197 CDC42 KRT27 MIPOL1 NECAB1 PNMA1 PRPF40A SUOX TXN2	51 interacting genes: - AGR3 AP1G1 AP1G2 AP1M2 ARF1 ARF5 ARF6 ARRB2 ATF7IP ATM ATR BARD1 BUB1 BUB1B CDC42EP1 CLTC CREBBP CRYBB1 CYTH4 FARS2 FBXO7 FMNL2 FNDC11 GPANK1 GTF2I KIF13A LDLRAP1 ME1 MLH1 MSGN1 MTNR1B MYG1 NECAP1 NTRK2 NUP54 PARD3 PHF5A PIP5K1C POM121 PRKDC PSME1 PSORS1C2 RNF39 SHBG SLC2A8 SMAD2 TBC1D22B TEX33 TSGA10IP U2AF1
Entrez ID		114793	162
HPRD ID		13545	02541
Ensembl ID		ENSG00000157827	ENSG00000100280
Uniprot IDs		Q96PY5	Q10567
PDB IDs		4YC7	4HMY 4P6Z 6CM9 6CRI 6D83 6D84 6DFF
Enriched GO Terms of Interacting Partners?
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