CHRNA4 and CHRNB4

  • Number of citations of the paper that reports this interaction (PubMedID 8906617)
  • 15
  • Data Source:
  • HPRD (in vitro)

CHRNA4

CHRNB4

Description cholinergic receptor nicotinic alpha 4 subunit cholinergic receptor nicotinic beta 4 subunit
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Attention function in attention deficit hyperactive disorder ( 26174813)
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • Benign childhood epilepsy with centro-temporal spikes ( 32580138)
  • BMI (smoking interaction) ( 28443625)
  • BMI in smokers ( 28443625)
  • Body mass index (joint analysis main effects and smoking interaction) ( 28443625)
  • Chronic obstructive pulmonary disease ( 30804561)
  • Chronic obstructive pulmonary disease x ever smoker interaction (1df) ( 33106845)
  • Coronary artery disease ( 32469254 33020668)
  • Diffusing capacity of carbon monoxide ( 30694715)
  • Exhaled carbon monoxide levels ( 25072098)
  • Gut microbiota relative abundance (Parabacteroides) ( 33208821)
  • Lung adenocarcinoma ( 28604730)
  • Lung cancer ( 31577861 28604730 18385738 18780872)
  • Lung cancer in ever smokers ( 28604730)
  • Nicotine dependence ( 18385739 26440539)
  • Post bronchodilator FEV1 ( 26634245)
  • Post bronchodilator FEV1/FVC ratio ( 26634245)
  • Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
  • Refractive error ( 32231278)
  • Schizophrenia ( 25056061 29483656)
  • Small cell lung carcinoma ( 28604730)
  • Smoking status (heavy vs light) ( 28520984)
  • Squamous cell lung carcinoma ( 28604730)
  • Sudden cardiac arrest ( 21658281)
Interacting Genes 8 interacting genes: CHRNB2 CHRNB4 CRELD2 CSNK2B RHOU UBQLN1 VSNL1 YWHAH 8 interacting genes: CHRNA2 CHRNA3 CHRNA4 CHRNA5 LARP7 MEOX2 SLC2A1 UBQLN1
Entrez ID 1137 1143
HPRD ID 00333 00337
Ensembl ID ENSG00000101204 ENSG00000117971
Uniprot IDs B4DK78 P43681 Q4VAQ3 Q59FV0 P30926
PDB IDs 2GVT 2LLY 5KXI 6CNJ 6CNK 6UR8 6USF 2ASG 6PV7 6PV8
Enriched GO Terms of Interacting Partners?
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