CIT and SELPLG

		CIT	SELPLG
Description		citron rho-interacting serine/threonine kinase	selectin P ligand
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Membrane	Uropod Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Plasma Membrane Raft
	Molecular Function	Transcription Coactivator Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding SH3 Domain Binding Protein Kinase Binding PDZ Domain Binding Protein Serine/threonine Kinase Inhibitor Activity Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity	Virus Receptor Activity Signaling Receptor Binding Protein Binding
	Biological Process	Mitotic Cell Cycle Mitotic Cytokinesis Peptidyl-threonine Phosphorylation Actomyosin Structure Organization Positive Regulation Of Cytokinesis Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Catalytic Activity Generation Of Neurons Neuron Apoptotic Process	Cell Adhesion Hemopoiesis Viral Entry Into Host Cell Leukocyte Migration Leukocyte Tethering Or Rolling Leukocyte Adhesive Activation Cellular Response To Interleukin-6
Pathways		RHO GTPases activate CIT RHO GTPases activate CIT RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle	Cell surface interactions at the vascular wall
Drugs		Fostamatinib
Diseases
GWAS		Mitochondrial heteroplasmy measurement ( 33731350) Number of sexual partners ( 30643258) Urgency urinary incontinence ( 25524241)	Acne (severe) ( 24927181) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Conduct disorder (symptom count) ( 20585324)
Interacting Genes		16 interacting genes: ABCB9 DERA DISC1 DLG4 ENPP7 GRIN1 GRIN2D HIP1R MLXIPL MTNR1A RAC1 RHOA RHOB RHOC RND3 SELPLG	17 interacting genes: BACE1 CIT CTSG ECSIT GALNT4 MAGEA1 MSN MVK SELE SELL SELP SLC13A1 SYK TNIP1 TPST1 TPST2 VCAN
Entrez ID		11113	6404
HPRD ID		09289	02845
Ensembl ID		ENSG00000122966	ENSG00000110876
Uniprot IDs		O14578	Q14242
PDB IDs			1G1S
Enriched GO Terms of Interacting Partners?
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