CIT and ABCB9

		CIT	ABCB9
Description		citron rho-interacting serine/threonine kinase	ATP binding cassette subfamily B member 9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Membrane	Lysosome Lysosomal Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane MHC Class I Peptide Loading Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Coactivator Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding SH3 Domain Binding Protein Kinase Binding PDZ Domain Binding Protein Serine/threonine Kinase Inhibitor Activity Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity	Protein Binding ATP Binding ABC-type Oligopeptide Transporter Activity ABC-type Peptide Antigen Transporter Activity ABC-type Peptide Transporter Activity Transmembrane Transporter Activity MHC Class I Protein Binding ATPase-coupled Transmembrane Transporter Activity Protein Homodimerization Activity TAP1 Binding
	Biological Process	Mitotic Cell Cycle Mitotic Cytokinesis Peptidyl-threonine Phosphorylation Actomyosin Structure Organization Positive Regulation Of Cytokinesis Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Catalytic Activity Generation Of Neurons Neuron Apoptotic Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Metabolic Process Protein Transport Peptide Transport Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Oligopeptide Transmembrane Transport Transmembrane Transport
Pathways		RHO GTPases activate CIT RHO GTPases activate CIT RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle	ABC-family proteins mediated transport
Drugs		Fostamatinib
Diseases
GWAS		Mitochondrial heteroplasmy measurement ( 33731350) Number of sexual partners ( 30643258) Urgency urinary incontinence ( 25524241)	Autism spectrum disorder or schizophrenia ( 28540026) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 34021172) Platelet count ( 21507922) Schizophrenia ( 28991256 25056061 29483656 23974872) Tourette syndrome ( 30818990) Triiodothyronine levels and thyroxine levels ( 30843173) Type 2 diabetes ( 28869590) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		16 interacting genes: ABCB9 DERA DISC1 DLG4 ENPP7 GRIN1 GRIN2D HIP1R MLXIPL MTNR1A RAC1 RHOA RHOB RHOC RND3 SELPLG	1 interacting genes: CIT
Entrez ID		11113	23457
HPRD ID		09289	09262
Ensembl ID		ENSG00000122966	ENSG00000150967
Uniprot IDs		O14578	A0A024RBU1 Q9NP78
PDB IDs
Enriched GO Terms of Interacting Partners?
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