PROCR and VKORC1

Number of citations of the paper that reports this interaction (PubMedID 21103663)
9

Data Source:
BioGRID (two hybrid)

		PROCR	VKORC1
Description		protein C receptor	vitamin K epoxide reductase complex subunit 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Centrosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Perinuclear Region Of Cytoplasm Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity	Protein Binding Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding
	Biological Process	Blood Coagulation Negative Regulation Of Coagulation	Xenobiotic Metabolic Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Bone Development
Pathways		Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall	Metabolism of vitamin K
Drugs		Drotrecogin alfa Phosphatidylethanolamine Tetradecyl hydrogen sulfate (ester)	Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anticoagulant levels ( 22216198) Blood protein levels ( 28240269) Coronary artery disease ( 29212778 33020668) D-dimer levels ( 21502573) Diastolic blood pressure ( 27618447) Factor VII activity ( 30642921) Factor VII activity or levels ( 30642921) Factor VII levels ( 20231535) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 23563607) Hemostatic factors and hematological phenotypes ( 22443383) Hip circumference adjusted for BMI ( 34021172) Myocardial infarction ( 33532862) Protein C levels ( 28082259 25376901 20802025) Prothrombin time ( 22703881 29403010) Thrombosis ( 26908601) Ulcerative colitis ( 23128233) Venous thromboembolism ( 25772935 31420334) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 20833655 19300499 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		3 interacting genes: DMTN PROC VKORC1	94 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CPLX4 CREB3 CREB3L1 CXADR DCTPP1 DPM2 ECHDC1 FAM209A FAM210B FGG FGL1 FIS1 FTL GJB1 GORAB GPR152 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA MANBAL METTL7B MSMO1 MSRB1 MT1X MUC1 PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMDN3 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC22A2 SLC25A1 SLC31A2 SLC7A14 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24
Entrez ID		10544	79001
HPRD ID		02801	10540
Ensembl ID		ENSG00000101000	ENSG00000167397
Uniprot IDs		Q9UNN8	A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6
PDB IDs		1L8J 1LQV 3JTC 4V3D 4V3E 6SNY	6WV3 6WV4 6WV5 6WV6 6WV7 6WVH
Enriched GO Terms of Interacting Partners?
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