PROCR and DMTN

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PROCR	DMTN
Description		protein C receptor	dematin actin binding protein
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Centrosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytosol Actin Filament Plasma Membrane Endomembrane System Postsynaptic Density Spectrin-associated Cytoskeleton Actin Cytoskeleton Cortical Cytoskeleton Platelet Dense Tubular Network Membrane Cell Projection Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Signaling Receptor Activity	Actin Binding Signaling Receptor Binding Protein Binding Spectrin Binding Protein Self-association Actin Filament Binding
	Biological Process	Blood Coagulation Negative Regulation Of Coagulation	Cytoskeleton Organization Regulation Of Cell Shape Regulation Of Lamellipodium Assembly Positive Regulation Of Fibroblast Migration Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Cell-substrate Adhesion Lamellipodium Assembly Actin Cytoskeleton Organization Positive Regulation Of Blood Coagulation Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Peptidyl-serine Phosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Calcium-mediated Signaling Using Extracellular Calcium Source Erythrocyte Development Negative Regulation Of Peptidyl-tyrosine Phosphorylation Actin Filament Bundle Assembly Regulation Of Filopodium Assembly Actin Filament Capping Negative Regulation Of Focal Adhesion Assembly Protein-containing Complex Assembly Protein Secretion By Platelet Cellular Response To Calcium Ion Cellular Response To CAMP Positive Regulation Of Wound Healing Negative Regulation Of Protein Targeting To Membrane Actin Filament Reorganization Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Platelet Aggregation Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall	Miscellaneous transport and binding events
Drugs		Drotrecogin alfa Phosphatidylethanolamine Tetradecyl hydrogen sulfate (ester)
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anticoagulant levels ( 22216198) Blood protein levels ( 28240269) Coronary artery disease ( 29212778 33020668) D-dimer levels ( 21502573) Diastolic blood pressure ( 27618447) Factor VII activity ( 30642921) Factor VII activity or levels ( 30642921) Factor VII levels ( 20231535) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 23563607) Hemostatic factors and hematological phenotypes ( 22443383) Hip circumference adjusted for BMI ( 34021172) Myocardial infarction ( 33532862) Protein C levels ( 28082259 25376901 20802025) Prothrombin time ( 22703881 29403010) Thrombosis ( 26908601) Ulcerative colitis ( 23128233) Venous thromboembolism ( 25772935 31420334) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Alanine aminotransferase levels ( 33547301) Apolipoprotein B levels ( 32203549) Gamma glutamyl transferase levels ( 33339817) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Total cholesterol levels ( 30275531)
Interacting Genes		3 interacting genes: DMTN PROC VKORC1	16 interacting genes: ACTB ACTC1 APP CEP76 DYNC1LI2 EPB42 GOLGA2 NEDD4L PRKACA PROCR PTOV1 SNCA SNRPD2 SPTB TEX11 TRAF2
Entrez ID		10544	2039
HPRD ID		02801	00506
Ensembl ID		ENSG00000101000	ENSG00000158856
Uniprot IDs		Q9UNN8	Q08495
PDB IDs		1L8J 1LQV 3JTC 4V3D 4V3E 6SNY	1QZP 1ZV6
Enriched GO Terms of Interacting Partners?
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