PROCR and PROC

Number of citations of the paper that reports this interaction (PubMedID 10681521)
30

Data Source:
HPRD (in vitro)

		PROCR	PROC
Description		protein C receptor	protein C, inactivator of coagulation factors Va and VIIIa
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Centrosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Lumen
	Molecular Function	Protein Binding Signaling Receptor Activity	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Blood Coagulation Negative Regulation Of Coagulation	Proteolysis Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Coagulation Positive Regulation Of Establishment Of Endothelial Barrier
Pathways		Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Drotrecogin alfa Phosphatidylethanolamine Tetradecyl hydrogen sulfate (ester)	Menadione Sodium tetradecyl sulfate Cupric Chloride Kappadione Protein S human
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anticoagulant levels ( 22216198) Blood protein levels ( 28240269) Coronary artery disease ( 29212778 33020668) D-dimer levels ( 21502573) Diastolic blood pressure ( 27618447) Factor VII activity ( 30642921) Factor VII activity or levels ( 30642921) Factor VII levels ( 20231535) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 23563607) Hemostatic factors and hematological phenotypes ( 22443383) Hip circumference adjusted for BMI ( 34021172) Myocardial infarction ( 33532862) Protein C levels ( 28082259 25376901 20802025) Prothrombin time ( 22703881 29403010) Thrombosis ( 26908601) Ulcerative colitis ( 23128233) Venous thromboembolism ( 25772935 31420334) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Blood protein levels ( 30072576) Protein C levels ( 28082259 25376901 20802025)
Interacting Genes		3 interacting genes: DMTN PROC VKORC1	17 interacting genes: CFLAR CP CSNK2B CYSRT1 F2 F5 F8 GGCX KLK1 NGLY1 PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1
Entrez ID		10544	5624
HPRD ID		02801	01466
Ensembl ID		ENSG00000101000	ENSG00000115718
Uniprot IDs		Q9UNN8	P04070
PDB IDs		1L8J 1LQV 3JTC 4V3D 4V3E 6SNY	1AUT 1LQV 1PCU 2PCT 3F6U 3JTC 4DT7 6M3B 6M3C
Enriched GO Terms of Interacting Partners?
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