WFDC2 and PANX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		WFDC2	PANX1
Description		WAP four-disulfide core domain 2	pannexin 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Membrane Integral Component Of Membrane Bleb Protein-containing Complex
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Aspartic-type Endopeptidase Inhibitor Activity	Protease Binding Signaling Receptor Binding Structural Molecule Activity Calcium Channel Activity Protein Binding Wide Pore Channel Activity Leak Channel Activity Transmembrane Transporter Binding Actin Filament Binding Gap Junction Hemi-channel Activity Scaffold Protein Binding
	Biological Process	Proteolysis Spermatogenesis Negative Regulation Of Endopeptidase Activity Antibacterial Humoral Response Innate Immune Response	Response To Ischemia Cation Transport Calcium Ion Transport Cell-cell Signaling Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Response To ATP Oogenesis Calcium Ion Transmembrane Transport
Pathways			Electric Transmission Across Gap Junctions The NLRP3 inflammasome
Drugs			Probenecid
Diseases
GWAS		Brain structure ( 20171287)	Alanine aminotransferase levels ( 33547301 34315874 33339817) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 33547301 34315874 29403010 33339817) Autoimmune thyroid disease ( 32581359) Liver enzyme levels (alanine transaminase) ( 33972514) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		17 interacting genes: ARL13B CD40 CD79A COQ9 CPLX4 CREB3L1 CYB5R3 FAM209A FKBP7 GORAB LMNA PANX1 PLS3 PTN SLC22A23 STOM TMX2	17 interacting genes: APOA2 APOL2 AQP2 BCL2L2 BUD31 CFHR5 CLCA4 FAXDC2 FDFT1 GNAS KEAP1 P2RX7 SLC38A7 TMEM229B TNF VAMP5 WFDC2
Entrez ID		10406	24145
HPRD ID		11684	10526
Ensembl ID		ENSG00000101443	ENSG00000110218
Uniprot IDs		A0A384MTN6 Q14508	A0A024R397 Q96RD7
PDB IDs			6LTN 6LTO 6M02 6M66 6M67 6M68 6V6D 6WBF 6WBG 6WBI 6WBK 6WBL 6WBM 6WBN
Enriched GO Terms of Interacting Partners?
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