PANX1 and APOL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PANX1	APOL2
Description		pannexin 1	apolipoprotein L2
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Membrane Integral Component Of Membrane Bleb Protein-containing Complex	Extracellular Region Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protease Binding Signaling Receptor Binding Structural Molecule Activity Calcium Channel Activity Protein Binding Wide Pore Channel Activity Leak Channel Activity Transmembrane Transporter Binding Actin Filament Binding Gap Junction Hemi-channel Activity Scaffold Protein Binding	Signaling Receptor Binding Protein Binding High-density Lipoprotein Particle Binding Lipid Binding
	Biological Process	Response To Ischemia Cation Transport Calcium Ion Transport Cell-cell Signaling Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Response To ATP Oogenesis Calcium Ion Transmembrane Transport	Lipid Metabolic Process Lipid Transport Acute-phase Response Multicellular Organism Development Cholesterol Metabolic Process Lipoprotein Metabolic Process Maternal Process Involved In Female Pregnancy
Pathways		Electric Transmission Across Gap Junctions The NLRP3 inflammasome
Drugs		Probenecid
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874 33339817) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 33547301 34315874 29403010 33339817) Autoimmune thyroid disease ( 32581359) Liver enzyme levels (alanine transaminase) ( 33972514) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Squamous cell lung carcinoma ( 28604730)	Epigenetic age acceleration in alcohol use disorder ( 31466081)
Interacting Genes		17 interacting genes: APOA2 APOL2 AQP2 BCL2L2 BUD31 CFHR5 CLCA4 FAXDC2 FDFT1 GNAS KEAP1 P2RX7 SLC38A7 TMEM229B TNF VAMP5 WFDC2	33 interacting genes: AIG1 APOC2 APOC4 AR BSND CISD2 CYBC1 EBAG9 EMP1 FAM209A GET1 GJB5 ITGB2 KCNA1 LMNA MARCHF3 MFF MGST3 PANX1 PSCA SFXN5 SIT1 SLC18A1 SLC26A6 STX1A STX2 TMED8 TMEM139 TMEM45B TMEM52B TMEM60 USE1 YIPF6
Entrez ID		24145	23780
HPRD ID		10526	06263
Ensembl ID		ENSG00000110218	ENSG00000128335
Uniprot IDs		A0A024R397 Q96RD7	A0A024R1M8 J3KQL8 Q9BQE5
PDB IDs		6LTN 6LTO 6M02 6M66 6M67 6M68 6V6D 6WBF 6WBG 6WBI 6WBK 6WBL 6WBM 6WBN
Enriched GO Terms of Interacting Partners?
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