WFDC2 and CD40

		WFDC2	CD40
Description		WAP four-disulfide core domain 2	CD40 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Extracellular Exosome	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface CD40 Receptor Complex Neuronal Cell Body Varicosity Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Aspartic-type Endopeptidase Inhibitor Activity	Antigen Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity
	Biological Process	Proteolysis Spermatogenesis Negative Regulation Of Endopeptidase Activity Antibacterial Humoral Response Innate Immune Response	Positive Regulation Of Protein Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Inflammatory Response B Cell Mediated Immunity CD40 Signaling Pathway Platelet Activation Positive Regulation Of B Cell Proliferation Positive Regulation Of Interleukin-12 Production Response To Cobalamin Response To Interferon-gamma TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Erythropoietin B Cell Proliferation B Cell Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Defense Response To Protozoan Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Protein-containing Complex Assembly Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Kinase C Signaling Response To Peptide Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
Drugs			Lucatumumab Dacetuzumab
Diseases
GWAS		Brain structure ( 20171287)	Blood protein levels in cardiovascular risk ( 28369058) Chronic hepatitis B infection ( 25802187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Hodgkin's lymphoma ( 30194254) Inflammatory bowel disease ( 28067908 23128233) Kawasaki disease ( 22446961 33106546 22446962) Multiple sclerosis ( 22190364 24076602 19525955 21833088) Rheumatoid arthritis ( 30423114 18794853 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systemic lupus erythematosus ( 28714469) Tonsillectomy ( 27182965 28928442)
Interacting Genes		17 interacting genes: ARL13B CD40 CD79A COQ9 CPLX4 CREB3L1 CYB5R3 FAM209A FKBP7 GORAB LMNA PANX1 PLS3 PTN SLC22A23 STOM TMX2	49 interacting genes: BIRC2 BIRC3 CAV1 CBL CD40LG CMTM5 CMTM6 CYB561A3 DEFB121 EBP EMP1 FAF1 HSPA4 HSPA8 IL4R INSIG2 JAK3 MAL MAP3K8 MFSD5 MIP MS4A1 NCOA6 NELFCD NSMAF PIK3R1 PLP1 RIPK2 RPS5 SLC30A2 SLC30A3 SLC39A13 SLC7A1 TANK TDP2 TLCD1 TMEM107 TMEM128 TMEM147 TP53TG5 TRAF1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRAF6 WFDC2 XRCC5 XRCC6
Entrez ID		10406	958
HPRD ID		11684	00178
Ensembl ID		ENSG00000101443	ENSG00000101017
Uniprot IDs		A0A384MTN6 Q14508	A0A0S2Z349 A0A0S2Z3C7 P25942 Q6P2H9
PDB IDs			1CDF 1CZZ 1D00 1FLL 1LB6 3QD6 5DMI 5DMJ 5IHL 6FAX 6PE8 6PE9
Enriched GO Terms of Interacting Partners?
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