BTN2A2 and SEC11C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		BTN2A2	SEC11C
Description		butyrophilin subfamily 2 member A2	SEC11 homolog C, signal peptidase complex subunit
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity
	Biological Process	Regulation Of Cytokine Production Negative Regulation Of Cytokine Production Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Activated T Cell Proliferation T Cell Receptor Signaling Pathway	Signal Peptide Processing
Pathways		Butyrophilin (BTN) family interactions	SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) General cognitive ability ( 29844566) Headache ( 29397368) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Liver iron content ( 34128465) Neurociticism ( 29500382) Refractive error ( 32231278) Schizophrenia ( 19571809) Smoking initiation ( 33082346) Subcortical volume (MOSTest) ( 32665545)	Alzheimer's disease (age of onset) ( 22005931) Chronotype ( 30696823) Morning person ( 30696823)
Interacting Genes		42 interacting genes: AQP6 BIK CD53 CD79A CISD2 CREB3 EBP ELOVL4 EMP1 ERGIC3 EVI2B FAM209A FATE1 FFAR2 GJB3 GPR42 GPRC5D GPX8 HSD3B7 KIR2DL3 LHFPL5 LMNA MRM3 MUC1 PEX12 PSMA3 SEC11C SLC10A6 SLC14A1 SLC16A2 SLC1A3 SLC30A4 SLC39A2 SPNS3 STX1A SYT1 TMEM14B TMEM179B TMEM237 TMEM31 TMEM52B TMX2	23 interacting genes: BTN2A2 C2 CADM3 GLP1R HMOX1 MFF PLPP6 PRSS23 RTP2 SCD SELENOM SERP1 STX12 TMEM128 TMEM243 TMEM254 TMEM42 TREX1 TSNARE1 UBE2J1 VAMP1 VAMP4 VAPA
Entrez ID		10385	90701
HPRD ID		12545	15310
Ensembl ID		ENSG00000124508	ENSG00000166562
Uniprot IDs		A0A024R038 Q8WVV5	K7EJQ7 Q9BY50
PDB IDs
Enriched GO Terms of Interacting Partners?
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