VPS26C and ARHGEF12

		VPS26C	ARHGEF12
Description		VPS26 endosomal protein sorting factor C	Rho guanine nucleotide exchange factor 12
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Endosome	Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Molecular_function Protein Binding	G Protein-coupled Receptor Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Intracellular Protein Transport Endocytic Recycling	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways			NRAGE signals death through JNK G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder symptom score ( 27663945) Coronary artery disease ( 29212778 30104761) Glaucoma ( 31959993 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935 25173105) Height ( 31562340) Intraocular pressure ( 29617998 25637523 31798171 29785010 31959993 30054594 28073927 29235454) Monocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)
Interacting Genes		26 interacting genes: ARHGEF12 CA14 CBLB CD55 DDX58 DECR2 DOP1B DSCR4 DSCR8 IFNL1 INCA1 LRIF1 MAML3 MAPK6 MDM4 MEI4 MEOX2 MSTO1 PIGP POU3F4 PTPN21 RAB39B SYNJ1 TEPSIN XPA ZNF655	18 interacting genes: ABCA1 CD44 CLK1 CUL3 EGFR GNA12 GNA13 IGF1R KLHL20 LPAR1 LPAR2 PLXNB1 PLXNB2 PTPRF RHOA RPS6KA1 TEC VPS26C
Entrez ID		10311	23365
HPRD ID		10390	09207
Ensembl ID		ENSG00000157538	ENSG00000196914
Uniprot IDs		A8MTY9 A8MY26 O14972	B4E2K6 E9PMR6 Q9NZN5
PDB IDs			1TXD 1X86 2OMJ 2OS6
Enriched GO Terms of Interacting Partners?
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