VPS26C and MDM4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		VPS26C	MDM4
Description		VPS26 endosomal protein sorting factor C	MDM4 regulator of p53
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Endosome	Nucleus Nucleoplasm
	Molecular Function	Molecular_function Protein Binding	P53 Binding Protein Binding Zinc Ion Binding Enzyme Binding
	Biological Process	Intracellular Protein Transport Endocytic Recycling	Negative Regulation Of Transcription By RNA Polymerase II Heart Valve Development Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Ventricular Septum Development Atrial Septum Development Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Protein Stabilization Regulation Of Cell Cycle Protein-containing Complex Assembly Cellular Response To Hypoxia
Pathways			Oxidative Stress Induced Senescence Oncogene Induced Senescence Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53
Drugs
Diseases
GWAS			Breast cancer ( 23535733 27117709) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast Cancer in BRCA1 mutation carriers ( 23544013) Cognitive performance ( 19734545) Diastolic blood pressure ( 27618452 30578418) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Fish- and plant-related diet ( 32066663) Glioma ( 28346443) Haemorrhoidal disease ( 33888516) Levodopa wearing off effect (time symptoms uncontrolled) in Parkinson's disease (response to zonisamide) ( 32355309) Non-glioblastoma glioma ( 28346443) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 23535732) Regular attendance at a religious group ( 29970889) Systolic blood pressure ( 27618452) Type 2 diabetes ( 32499647)
Interacting Genes		26 interacting genes: ARHGEF12 CA14 CBLB CD55 DDX58 DECR2 DOP1B DSCR4 DSCR8 IFNL1 INCA1 LRIF1 MAML3 MAPK6 MDM4 MEI4 MEOX2 MSTO1 PIGP POU3F4 PTPN21 RAB39B SYNJ1 TEPSIN XPA ZNF655	65 interacting genes: AKT1 APP ARF1 ATM BECN1 C1orf109 CAPN7 CASP3 CBLC CD160 CD44 CDK1 CDK4 CDKN2A CDKN2B CHEK1 CHEK2 CSNK1A1 E2F1 EP300 EPHA2 FGFR4 GLIS2 HGF LATS2 LRSAM1 MAGEA1 MAP2K5 MDM2 MKRN3 MNAT1 NAA10 NF2 PELI1 PRKAA1 RAD54B RB1 RNF115 S100B SFN SMAD3 SMAD4 SMARCA2 TOP2A TP53 TP63 TP73 TRIM46 TRIM55 UBC UBE2D1 UBE2D2 UBE2D3 USP7 VPS26C WDR5 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZCCHC2 ZKSCAN3 ZKSCAN4
Entrez ID		10311	4194
HPRD ID		10390	04082
Ensembl ID		ENSG00000157538	ENSG00000198625
Uniprot IDs		A8MTY9 A8MY26 O14972	A0A087WTR9 A0A087WUE3 A0A087WZ58 O15151 Q59FS6 Q68DC0
PDB IDs			2CR8 2MWY 2N06 2N0U 2N0W 2N14 2VJE 2VJF 2VYR 3DAB 3EQY 3FDO 3FE7 3FEA 3JZO 3JZP 3JZQ 3LBJ 3MQR 3U15 4RXZ 5MNJ 5UML 5VK1 6Q9Q 6Q9S 6Q9U 6Q9W 6Q9Y 7C3Q 7C3Y 7C44
Enriched GO Terms of Interacting Partners?
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