ARHGEF12 and LPAR1

Number of citations of the paper that reports this interaction (PubMedID 15755723)
44

Data Source:
HPRD (in vitro, in vivo)

		ARHGEF12	LPAR1
Description		Rho guanine nucleotide exchange factor 12	lysophosphatidic acid receptor 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Extracellular Exosome	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle
	Molecular Function	G Protein-coupled Receptor Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding	G Protein-coupled Receptor Activity Protein Binding Lysophosphatidic Acid Binding Lysophosphatidic Acid Receptor Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cell Shape Negative Regulation Of Neuron Projection Development Regulation Of Metabolic Process Neurogenesis Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Stress Fiber Assembly Cell Chemotaxis
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle	G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder symptom score ( 27663945) Coronary artery disease ( 29212778 30104761) Glaucoma ( 31959993 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935 25173105) Height ( 31562340) Intraocular pressure ( 29617998 25637523 31798171 29785010 31959993 30054594 28073927 29235454) Monocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)	Birth weight ( 31043758 27680694) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 31798171 29760442 30894546) Corneal structure ( 23291589) Cortical thickness ( 32963231) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Height ( 20881960 25282103 31562340) Monocyte count ( 28193307 29403010 32888494 28031487) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Offspring birth weight ( 31043758) Post bronchodilator FEV1 in COPD ( 26634245) Pursuit maintenance gain ( 29064472) Sum eosinophil basophil counts ( 27863252) White blood cell count (monocyte) ( 28158719) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		18 interacting genes: ABCA1 CD44 CLK1 CUL3 EGFR GNA12 GNA13 IGF1R KLHL20 LPAR1 LPAR2 PLXNB1 PLXNB2 PTPRF RHOA RPS6KA1 TEC VPS26C	7 interacting genes: ARHGEF11 ARHGEF12 DRD2 GIPC1 GNAI3 KRAS SLC9A3R2
Entrez ID		23365	1902
HPRD ID		09207	03790
Ensembl ID		ENSG00000196914	ENSG00000198121
Uniprot IDs		B4E2K6 E9PMR6 Q9NZN5	Q5VZX0 Q92633
PDB IDs		1TXD 1X86 2OMJ 2OS6	4Z34 4Z35 4Z36
Enriched GO Terms of Interacting Partners?
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