CDH13 and CHEK2

  • Number of citations of the paper that reports this interaction (PubMedID 25640309)
  • 8
  • Data Source:
  • BioGRID (two hybrid)

CDH13

CHEK2

Description cadherin 13 checkpoint kinase 2
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Adiponectin levels ( 20876611 22479202 22065538 31178129 20887962 21771975 24105470)
  • Adolescent idiopathic scoliosis ( 31417091 30395268)
  • Adult body size ( 32376654)
  • Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145)
  • Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) ( 24025145)
  • Alcohol consumption (heavy vs. light/non-drinkers) ( 27911795)
  • Anthracycline-induced cardiotoxicity in early breast cancer ( 32378780)
  • Attention deficit hyperactivity disorder ( 18839057)
  • Bipolar disorder ( 31043756)
  • Blood pressure ( 17903302)
  • Bortezomib-induced peripheral neuropathy in multiple myeloma ( 28317148)
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
  • Coronary artery disease ( 29212778 30104761 28714974 33020668)
  • Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975)
  • Crohn's disease ( 28067908)
  • D-dimer levels ( 21502573)
  • Daytime sleep phenotypes ( 27126917)
  • Declining hemoglobin trajectory in blood donors ( 33491795)
  • Dental caries (decayed, missing and filled teeth) ( 31533690)
  • Depression (quantitative trait) ( 20800221)
  • Diastolic blood pressure ( 27841878 31170924 30578418)
  • Dimensional psychopathology (Arousal) ( 29496196)
  • Dimensional psychopathology (Negative) ( 29496196)
  • Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
  • Erectile dysfunction ( 30583798)
  • Feeling hurt ( 29500382)
  • Feeling tense ( 29500382)
  • Fish- and plant-related diet ( 32066663)
  • Gait speed in old age ( 28077804)
  • General risk tolerance (MTAG) ( 30643258)
  • Glucose homeostasis traits ( 25524916)
  • Gut microbiota relative abundance (Blautia) ( 33208821)
  • Gut microbiota relative abundance (Prevotella) ( 33208821)
  • Height ( 20189936)
  • Hippocampal volume ( 31530798)
  • Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828)
  • Hypertension ( 19304780)
  • Hypothyroidism ( 27182965)
  • IgE levels in asthmatics (D.f. specific) ( 23967269)
  • Leukoderma in response to rhododendrol ( 32558222)
  • Maximal oxygen uptake response ( 25729143)
  • Myocardial infarction ( 33532862)
  • Night sleep phenotypes ( 27126917)
  • Oily fish consumption ( 32066663)
  • Periodontitis (Mean PAL) ( 24024966)
  • Pork consumption ( 32066663)
  • Post bronchodilator FEV1/FVC ratio ( 26634245)
  • PR interval ( 32439900)
  • Precuneus cortex volume ( 31530798)
  • Pulse pressure ( 28135244 27841878 28739976 30578418)
  • Rapid automised naming of digits ( 30741946)
  • Refractive astigmatism ( 30306274)
  • Response to amphetamines ( 22952603)
  • Response to antipsychotic treatment ( 20195266)
  • Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
  • Response to fenofibrate (adiponectin levels) ( 23149075)
  • Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872)
  • Schizophrenia ( 23358160)
  • Seasonality and depression ( 30217971)
  • Short-term memory (digit-span task) ( 30741946)
Interacting Genes 10 interacting genes: ADIPOQ AURKA CASP8 CCND1 CHEK2 HMMR MAPK6 MTNR1B PTPN1 RAD51 85 interacting genes: AATF APP ARHGAP1 ASF1A ATM ATR BAALC BEX1 BRCA1 BRCA2 CCL5 CDC25A CDC25C CDH13 CDK11B CDKN1A CRKL CYP17A1 DAPK3 DBF4 DIRAS3 E2F1 ELAVL1 ENO1 ERCC6 FHL1 FHL3 FOXM1 FUS GNAS GRK3 HMGN1 HOXC6 ITIH5 KLK7 KLK9 KPNA2 LATS2 LYPD3 MAPT MDC1 MDM2 MDM4 MN1 MRC1 MSH2 MUS81 NBN NR4A1 NSD3 PLK1 PLK3 POLR2L PPM1D PPP2CA PPP2R2A PPP2R2B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRDM14 PRKDC PRMT2 PSMC3IP PSME3 RAD9A RCHY1 REV3L RHOBTB2 RNF8 SIAH2 SLC25A6 SRPK1 SRPK2 ST14 STMN1 STRAP SUSD2 TLR3 TP53 TSSK1B USP39 VHL
Entrez ID 1012 11200
HPRD ID 03219 05084
Ensembl ID ENSG00000140945 ENSG00000183765
Uniprot IDs B7Z3H7 B7Z9B1 P55290 O96017
PDB IDs 2V37 1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R 4A9S 4A9T 4A9U 4BDA 4BDB 4BDC 4BDD 4BDE 4BDF 4BDG 4BDH 4BDI 4BDJ 4BDK
Enriched GO Terms of Interacting Partners?
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