HUWE1 and PCNA

Number of citations of the paper that reports this interaction (PubMedID 27146073)
23

Data Source:
BioGRID (pull down)

		HUWE1	PCNA
Description		HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	proliferating cell nuclear antigen
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromosome, Telomeric Region Chromatin Nucleus Nuclear Lamina Nucleoplasm Replication Fork Centrosome Nuclear Body Replisome Nuclear Replication Fork PCNA Complex Extracellular Exosome PCNA-p21 Complex
	Molecular Function	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Chromatin Binding Damaged DNA Binding Protein Binding Protein C-terminus Binding Enzyme Binding Estrogen Receptor Binding DNA Polymerase Processivity Factor Activity Receptor Tyrosine Kinase Binding Dinucleotide Insertion Or Deletion Binding MutLalpha Complex Binding Histone Acetyltransferase Binding Identical Protein Binding Protein-containing Complex Binding DNA Polymerase Binding
	Biological Process	Protein Polyubiquitination Base-excision Repair Protein Monoubiquitination Golgi Organization Negative Regulation Of Mitochondrial Fusion Protein Ubiquitination Histone Ubiquitination Cell Differentiation Positive Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Membrane Fusion Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization Positive Regulation Of Protein Targeting To Mitochondrion	Negative Regulation Of Transcription By RNA Polymerase II Leading Strand Elongation Base-excision Repair, Gap-filling Mismatch Repair Heart Development Translesion Synthesis Epithelial Cell Differentiation Replication Fork Processing Positive Regulation Of Deoxyribonuclease Activity Response To Estradiol Cellular Response To UV Estrous Cycle Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Response To Cadmium Ion Cellular Response To Hydrogen Peroxide Cellular Response To Xenobiotic Stimulus Response To Dexamethasone Liver Regeneration Positive Regulation Of DNA-directed DNA Polymerase Activity Response To L-glutamate Mitotic Telomere Maintenance Via Semi-conservative Replication
Pathways		Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Transcription of E2F targets under negative control by DREAM complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand SUMOylation of DNA replication proteins Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription E3 ubiquitin ligases ubiquitinate target proteins
Drugs			Liothyronine Acetylsalicylic acid
Diseases
GWAS		Bipolar disorder ( 31043756) Body mass index ( 28892062) Educational attainment (years of education) ( 30038396)
Interacting Genes		39 interacting genes: ABL1 ATOH1 CALM1 CASP1 CCL1 CDKN2A CREBBP CTNNB1 CUL4B ERG H2AX HDAC2 HSPB1 LAPTM5 MCL1 MYCN PCNA PIAS2 POLB POLL PPP5C RBBP7 RNF11 SMAD2 SMAD9 SUMO2 TBP TNS2 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2L3 USP4 USP7 WBP2 WIPI2	141 interacting genes: ALDOA APEX1 APEX2 ATAD5 BAZ1B CBX1 CCNB1 CCND1 CCND3 CCNO CDC25C CDC6 CDK1 CDK2 CDK5 CDK6 CDKN1A CDKN1C CDKN2A CDT1 CHAF1A CHTF18 CHTF8 CMTM5 CREBBP DHX9 DNMT1 DNTT DNTTIP2 DSCC1 DTL EGFR ENO1 EP300 ERCC5 ERCC6 ERRFI1 ESCO2 EXO1 FAN1 FANCD2 FANCL FEN1 GADD45A GADD45B GADD45G GAPDH GCK GPI HDAC1 HUS1 HUWE1 ING1 KCTD13 KMT5A LDHA LIG1 LMNA MCL1 MGMT MLH1 MLH3 MSH2 MSH3 MSH6 MUTYH MYBBP1A NF2 NMRAL1 NSD2 NTHL1 NUTF2 PARP1 PARP10 PARPBP PCLAF PFKM PGAM1 PGK1 PKLR PMS2 POLB POLD1 POLD2 POLD3 POLD4 POLDIP2 POLE POLH POLI POLK POLL POLM PPP1CA PRKDC PTEN PTMA RAD9A RBBP8 RECQL5 RFC1 RFC2 RFC3 RFC4 RFC5 RFWD3 RNF8 RPA1 SDE2 SEC23IP SIVA1 SLC30A8 SMARCAD1 SPG21 SUB1 SUMO1 TCOF1 TDG TIRAP TMEM218 TPI1 TRIM28 UBB UBE2A UBE2B UBE2D3 UBE2I UHRF1 UNG USP1 USP2 USP4 WDR48 WRN WRNIP1 XPA XRCC1 XRCC5 XRCC6 YBX1 ZBTB1
Entrez ID		10075	5111
HPRD ID		06608	01456
Ensembl ID		ENSG00000086758	ENSG00000132646
Uniprot IDs		A0A024R9W5 Q7Z6Z7	P12004
PDB IDs		2EKK 2MUL 3G1N 3H1D 5C6H 5LP8 6FYH 6MIW 6PFL	1AXC 1U76 1U7B 1UL1 1VYJ 1VYM 1W60 2ZVK 2ZVL 2ZVM 3JA9 3P87 3TBL 3VKX 3WGW 4D2G 4RJF 4ZTD 5E0T 5E0U 5E0V 5IY4 5MAV 5MLO 5MLW 5MOM 5YCO 5YD8 6CBI 6EHT 6FCM 6FCN 6GIS 6GWS 6HVO 6K3A 6QC0 6QCG 6S1M 6S1N 6S1O 6TNY 6TNZ 6VVO
Enriched GO Terms of Interacting Partners?
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