HUWE1 and RBBP7

Number of citations of the paper that reports this interaction (PubMedID 29738775)
3

Data Source:
BioGRID (affinity chromatography technology, pull down, enzymatic study)

		HUWE1	RBBP7
Description		HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	RB binding protein 7, chromatin remodeling factor
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Histone Deacetylase Complex Nucleus Nucleoplasm Cytosol NuRD Complex ESC/E(Z) Complex
	Molecular Function	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity	RNA Binding Protein Binding Histone Binding
	Biological Process	Protein Polyubiquitination Base-excision Repair Protein Monoubiquitination Golgi Organization Negative Regulation Of Mitochondrial Fusion Protein Ubiquitination Histone Ubiquitination Cell Differentiation Positive Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Membrane Fusion Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization Positive Regulation Of Protein Targeting To Mitochondrion	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Chromatin Organization Negative Regulation Of Cell Growth Response To Steroid Hormone Cellular Heat Acclimation
Pathways		Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation	PRC2 methylates histones and DNA Oxidative Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines HATs acetylate histones RMTs methylate histone arginines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Activation of anterior HOX genes in hindbrain development during early embryogenesis Deposition of new CENPA-containing nucleosomes at the centromere Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Neddylation Transcriptional Regulation by E2F6 HCMV Early Events Potential therapeutics for SARS Defective pyroptosis
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Body mass index ( 28892062) Educational attainment (years of education) ( 30038396)	Refractive error ( 32231278)
Interacting Genes		39 interacting genes: ABL1 ATOH1 CALM1 CASP1 CCL1 CDKN2A CREBBP CTNNB1 CUL4B ERG H2AX HDAC2 HSPB1 LAPTM5 MCL1 MYCN PCNA PIAS2 POLB POLL PPP5C RBBP7 RNF11 SMAD2 SMAD9 SUMO2 TBP TNS2 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2L3 USP4 USP7 WBP2 WIPI2	35 interacting genes: APPL1 APPL2 BCL11A BCL11B BRCA1 BRMS1 BRMS1L BUB3 CREBBP CYTOR DHX30 ERCC6 ESR1 FOXK2 H3-4 H3C1 HDAC1 HDAC2 HUWE1 ING1 MBD3 MBD3L2 MTA2 NR2E3 OGT PRKAA2 RB1 RBBP4 RBP1 SALL2 SAP30 SIN3A SUMO2 SUV39H1 TWIST1
Entrez ID		10075	5931
HPRD ID		06608	04231
Ensembl ID		ENSG00000086758	ENSG00000102054
Uniprot IDs		A0A024R9W5 Q7Z6Z7	Q16576 Q6FHQ0
PDB IDs		2EKK 2MUL 3G1N 3H1D 5C6H 5LP8 6FYH 6MIW 6PFL	3CFS 3CFV
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?