PCNA and FEN1

  • Number of citations of the paper that reports this interaction (PubMedID 7673186)
  • 103
  • Data Source:
  • BioGRID (affinity chromatography technology)
  • HPRD (in vivo, in vitro, two hybrid)

PCNA

FEN1

Description proliferating cell nuclear antigen flap structure-specific endonuclease 1
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Asthma ( 31959851 31619474)
  • Bipolar disorder ( 28115744 31043756)
  • Bipolar I disorder ( 31043756)
  • Brain morphology (MOSTest) ( 32665545)
  • Colorectal cancer ( 24836286)
  • Colorectal cancer or advanced adenoma ( 30510241)
  • Crohn's disease ( 28067908)
  • Daytime nap ( 33568662)
  • Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731)
  • Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
  • Hemoglobin levels ( 32327693)
  • Laryngeal squamous cell carcinoma ( 25194280)
  • Male-pattern baldness ( 28196072)
  • Metabolite levels ( 23823483 23378610)
  • Oleic acid (18:1n-9) levels ( 23362303)
  • Palmitoleic acid (16:1n-7) levels ( 23362303)
  • Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377)
  • Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377)
  • Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377)
  • Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311)
  • Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311)
  • Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311)
  • Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311)
  • Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311)
  • Platelet count ( 22139419)
  • QT interval ( 29874175)
  • Red blood cell fatty acid levels ( 25500335)
  • Refractive error ( 32231278)
  • Resting heart rate ( 27798624)
  • Serum metabolite levels ( 23093944)
  • Serum metabolite ratios in chronic kidney disease ( 29545352)
  • Stearic acid (18:0) levels ( 23362303)
Interacting Genes 141 interacting genes: ALDOA APEX1 APEX2 ATAD5 BAZ1B CBX1 CCNB1 CCND1 CCND3 CCNO CDC25C CDC6 CDK1 CDK2 CDK5 CDK6 CDKN1A CDKN1C CDKN2A CDT1 CHAF1A CHTF18 CHTF8 CMTM5 CREBBP DHX9 DNMT1 DNTT DNTTIP2 DSCC1 DTL EGFR ENO1 EP300 ERCC5 ERCC6 ERRFI1 ESCO2 EXO1 FAN1 FANCD2 FANCL FEN1 GADD45A GADD45B GADD45G GAPDH GCK GPI HDAC1 HUS1 HUWE1 ING1 KCTD13 KMT5A LDHA LIG1 LMNA MCL1 MGMT MLH1 MLH3 MSH2 MSH3 MSH6 MUTYH MYBBP1A NF2 NMRAL1 NSD2 NTHL1 NUTF2 PARP1 PARP10 PARPBP PCLAF PFKM PGAM1 PGK1 PKLR PMS2 POLB POLD1 POLD2 POLD3 POLD4 POLDIP2 POLE POLH POLI POLK POLL POLM PPP1CA PRKDC PTEN PTMA RAD9A RBBP8 RECQL5 RFC1 RFC2 RFC3 RFC4 RFC5 RFWD3 RNF8 RPA1 SDE2 SEC23IP SIVA1 SLC30A8 SMARCAD1 SPG21 SUB1 SUMO1 TCOF1 TDG TIRAP TMEM218 TPI1 TRIM28 UBB UBE2A UBE2B UBE2D3 UBE2I UHRF1 UNG USP1 USP2 USP4 WDR48 WRN WRNIP1 XPA XRCC1 XRCC5 XRCC6 YBX1 ZBTB1 19 interacting genes: APEX1 APP ARHGDIA BLM CCNA2 CDK1 CDK2 EEF1G EP300 GSK3B HNRNPA1 HUS1 OGT PCNA RAD1 RAD9A TERF1 WDR4 WRN
Entrez ID 5111 2237
HPRD ID 01456 02670
Ensembl ID ENSG00000132646 ENSG00000168496
Uniprot IDs P12004 P39748 Q6FHX6
PDB IDs 1AXC 1U76 1U7B 1UL1 1VYJ 1VYM 1W60 2ZVK 2ZVL 2ZVM 3JA9 3P87 3TBL 3VKX 3WGW 4D2G 4RJF 4ZTD 5E0T 5E0U 5E0V 5IY4 5MAV 5MLO 5MLW 5MOM 5YCO 5YD8 6CBI 6EHT 6FCM 6FCN 6GIS 6GWS 6HVO 6K3A 6QC0 6QCG 6S1M 6S1N 6S1O 6TNY 6TNZ 6VVO 1U7B 1UL1 3Q8K 3Q8L 3Q8M 3UVU 5E0V 5FV7 5K97 5KSE 5UM9 5ZOD 5ZOE 5ZOF 5ZOG 6TNZ
Enriched GO Terms of Interacting Partners?
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