THOC1 and WDR77

Number of citations of the paper that reports this interaction (PubMedID 22365833)
132

Data Source:
BioGRID (two hybrid)

		THOC1	WDR77
Description		THO complex 1	WD repeat domain 77
Image
GO Annotations	Cellular Component	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Methylosome
	Molecular Function	DNA Binding RNA Binding Protein Binding	Protein Binding Methyl-CpG Binding Nuclear Receptor Transcription Coactivator Activity
	Biological Process	Regulation Of DNA Recombination RNA Processing RNA Export From Nucleus MRNA Export From Nucleus Apoptotic Process Signal Transduction RNA Splicing MRNA 3'-end Processing Replication Fork Processing Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus Negative Regulation Of Isotype Switching To IgA Isotypes Negative Regulation Of DNA Damage Checkpoint	Spliceosomal SnRNP Assembly Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Proliferation Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Nucleic Acid-templated Transcription
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination	snRNP Assembly RMTs methylate histone arginines
Drugs
Diseases
GWAS		Bipolar disorder ( 20351715) Bipolar disorder or major depressive disorder ( 20351715) Height ( 31562340) Menarche (age at onset) ( 29773799)
Interacting Genes		14 interacting genes: ATP1B1 DHX8 FRA10AC1 IK MOAP1 MTNR1B NEDD4 RABGEF1 RB1 SAP30BP SF3B2 TRIM54 USHBP1 WDR77	44 interacting genes: AQR BAG2 CDK19 CDK8 CLNS1A CREBBP CTDP1 GLI1 GPKOW H2AC21 HNRNPM LSM3 NKX3-1 PCBP2 PITRM1 PPIL1 PPP1R8 PQBP1 PRKG1 PRKG2 PRMT5 QKI RBM5 RIOK1 SAP30BP SF1 SF3A1 SF3B4 SIRT7 SMAD1 SMYD1 SNRPB SNRPC SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SUZ12 THOC1 TOE1 YWHAB YWHAQ ZNF207
Entrez ID		9984	79084
HPRD ID		09498	14387
Ensembl ID		ENSG00000079134	ENSG00000116455
Uniprot IDs		Q96FV9	A0A024R0H7 Q9BQA1
PDB IDs		1WXP	4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S
Enriched GO Terms of Interacting Partners?
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