SRGAP3 and WASF1

Number of citations of the paper that reports this interaction (PubMedID 12447388)
65

Data Source:
HPRD (in vivo, in vitro)

		SRGAP3	WASF1
Description		SLIT-ROBO Rho GTPase activating protein 3	WASP family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Mitochondrial Outer Membrane Cytoskeleton Focal Adhesion Actin Cytoskeleton Lamellipodium SCAR Complex Dendrite Cytoplasm Protein-containing Complex Postsynapse
	Molecular Function	GTPase Activator Activity Protein Binding Rac GTPase Binding	Actin Binding Protein Binding Rac GTPase Binding Protein Kinase A Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Migration Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Receptor-mediated Endocytosis Rac Protein Signal Transduction Actin Filament Polymerization Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein-containing Complex Assembly Lamellipodium Morphogenesis Dendrite Extension Modification Of Postsynaptic Actin Cytoskeleton Dendritic Transport Of Mitochondrion Cellular Response To Brain-derived Neurotrophic Factor Stimulus Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Rho GTPase cycle Inactivation of CDC42 and RAC1	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Body fat percentage ( 31752434) Lead levels in blood ( 25820613) Rapid automised naming of letters ( 30741946)
Interacting Genes		9 interacting genes: DISC1 DTNBP1 FASLG KDM1A PRMT6 SMARCC2 SUV39H1 TNIK WASF1	31 interacting genes: ABI1 ABL1 ACTB ACTG1 ACTR2 ACTR3 BAD BAIAP2 BRK1 CDC42 CDK5 CRK CXCL8 CYFIP2 DNMBP FYN GNAI1 GRB2 IFT20 IL12A MAPKAPK2 NCK1 NCKAP1 NYAP2 PFN1 PRKAR2A PSTPIP1 RAC1 SORBS2 SRGAP3 TRIP10
Entrez ID		9901	8936
HPRD ID		12108	05434
Ensembl ID		ENSG00000196220	ENSG00000112290
Uniprot IDs		O43295	Q92558
PDB IDs			3P8C 4N78
Enriched GO Terms of Interacting Partners?
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