DOCK1 and RAC1

  • Number of citations of the paper that reports this interaction (PubMedID 12134158)
  • 189
  • Data Source:
  • BioGRID (biochemical, affinity chromatography technology, pull down)
  • HPRD (in vivo, in vitro)

DOCK1

RAC1

Description dedicator of cytokinesis 1 Rac family small GTPase 1
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Airway wall thickness ( 25517131)
  • Apolipoprotein Levels ( 23031429)
  • Body mass index ( 25673413)
  • Body mass index (change over time) in gastrointestinal cancer ( 28044437)
  • Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437)
  • BRCA1/2-negative high-risk breast cancer ( 30323354)
  • Chronotype ( 30696823)
  • Homeostasis model assessment of insulin resistance in less-fat diet ( 30327367)
  • Response to cytidine analogues (gemcitabine) ( 24483146)
  • Response to TNF inhibitor in rheumatoid arthritis (change in disease activity score) ( 30166627)
  • Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627)
  • Social communication problems ( 24564958)
  • Weight ( 28552196)
  • Basal cell carcinoma ( 31174203)
  • Body mass index ( 26426971)
  • Coronary artery disease ( 29212778)
  • Keratinocyte cancer (MTAG) ( 31174203)
  • Medication use (agents acting on the renin-angiotensin system) ( 31015401)
  • Red cell distribution width ( 27863252)
Interacting Genes 11 interacting genes: BCAR1 CRK CYTH2 ELMO1 ELMO2 NCK2 PRKACA RAC1 RHOG TAMALIN WASF2 153 interacting genes: ACTA1 ACTB AGAP1 AGAP2 AKT1 ARFIP2 ARHGAP1 ARHGAP15 ARHGAP17 ARHGAP27 ARHGAP31 ARHGAP32 ARHGAP33 ARHGAP35 ARHGAP44 ARHGDIA ARHGDIB ARHGDIG ARHGEF2 ARHGEF25 ARHGEF4 ARHGEF7 ARL2BP BAG6 BAIAP2 BCR BIRC2 BRINP1 CASP3 CASP7 CAV1 CDC23 CDC42BPG CDC42SE1 CDC42SE2 CFAP36 CHN1 CHN2 CIT COG5 CORO1C CSN2 CYBA CYBB CYFIP1 DEF6 DIAPH1 DIAPH3 DMPK DOCK1 DOCK2 DOCK7 DOCK8 DVL1 DVL2 EIF2AK2 ENAH FHOD1 FLNA FMN2 FMNL1 GRN HACD3 HACE1 HPS4 ICMT IFNGR1 IL1RAP IQGAP1 IQGAP2 KPNA4 KPNA6 KRT40 KTN1 LATS1 LRP2 LTBP3 LTBP4 LZTS2 MAGI1 MAP3K10 MAP3K11 MAP3K4 MCF2L MCM3AP METAP2 MT-CO3 MTNR1A MYD88 MYH9 NCF2 NCK1 NCKAP1 NEDD4 NME1 NOS2 NOXA1 NR2C2 OCRL OPHN1 PAK1 PAK2 PAK3 PAK5 PAK6 PARD6A PARD6B PARD6G PIAS3 PIK3R1 PIP4K2A PLD1 PLEKHG2 PLXNB1 PPP2R2B PRKCA PRKCD PRKCI PRKN PRMT6 PTK2 RALBP1 RAP1GDS1 RASGRF1 RCC2 RGL2 RPS6KB1 SET SFPQ SH3BP1 SH3RF1 SH3RF3 SNX31 STAT1 STAT3 STAU1 SYNJ2 TBC1D3F TIAM1 TLR2 TNFRSF12A TRIO TUBA4A UBC UNKL USH1C USP6 VAV1 VAV2 VAV3 VWF WAS WASF1
Entrez ID 1793 5879
HPRD ID 03240 03627
Ensembl ID ENSG00000150760 ENSG00000136238
Uniprot IDs A0A2X0U2H5 B2RUU3 Q14185 A4D2P0 A4D2P1 P63000
PDB IDs 3L4C 1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2RMK 2VRW 2WKP 2WKQ 2WKR 2YIN 3B13 3BJI 3RYT 3SBD 3SBE 3SU8 3SUA 3TH5 4GZL 4GZM 4YON 5FI0 5HZH 5N6O 5O33 6AGP 6BC1
Enriched GO Terms of Interacting Partners?
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