SNX17 and LRP8

Number of citations of the paper that reports this interaction (PubMedID 12169628)
42

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SNX17	LRP8
Description		sorting nexin 17	LDL receptor related protein 8
Image
GO Annotations	Cellular Component	Endosome Early Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Intracellular Membrane-bounded Organelle	Extracellular Region Microtubule Associated Complex Plasma Membrane Caveola Postsynaptic Density Membrane Integral Component Of Membrane Axon Dendrite Neuronal Cell Body Receptor Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Protein C-terminus Binding Phosphatidylinositol Binding Low-density Lipoprotein Particle Receptor Binding	Transmembrane Signaling Receptor Activity Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding High-density Lipoprotein Particle Binding Kinesin Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Cargo Receptor Activity Reelin Receptor Activity
	Biological Process	Cardiac Septum Development Cholesterol Catabolic Process Intracellular Protein Transport Receptor-mediated Endocytosis Signal Transduction Endosomal Transport Regulation Of Endocytosis Endocytic Recycling Aorta Development Coronary Vasculature Development Retrograde Transport, Endosome To Plasma Membrane	Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Endocytosis Signal Transduction Cytokine-mediated Signaling Pathway Ammon Gyrus Development Cerebral Cortex Development Positive Regulation Of CREB Transcription Factor Activity Reelin-mediated Signaling Pathway Response To Drug Regulation Of Apoptotic Process Regulation Of Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Modulation Of Chemical Synaptic Transmission Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cholesterol Positive Regulation Of Dendrite Development
Pathways			Platelet sensitization by LDL Retinoid metabolism and transport
Drugs
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Crohn's disease ( 28067908) High light scatter reticulocyte count ( 27863252) Inflammatory bowel disease ( 28067908) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Microalbuminuria ( 31511532) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 30910378 31511532) Urinary sodium to potassium ratio ( 30910378)	Blood protein levels ( 30072576) Body mass index (alcohol intake interaction) ( 23192594) Cerebrospinal fluid AB1-42 levels ( 28247064) General risk tolerance (MTAG) ( 30643258) Number of sexual partners ( 30643258) Type 2 diabetes nephropathy ( 30566433) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		11 interacting genes: ANXA2 APP HRAS LDLR LRP1 LRP2 LRP8 RLIM SELP SKIL VLDLR	21 interacting genes: ANAPC10 APBA2 APOE APOH CLU DAB1 DAB2 DLG4 GIPC1 GRIN1 ITGB1BP1 LRPAP1 MAPK8IP1 MAPK8IP2 MDK MYLIP NOS1AP RELN SCN3A SNX17 SYNJ2BP
Entrez ID		9784	7804
HPRD ID		05812	04002
Ensembl ID		ENSG00000115234	ENSG00000157193
Uniprot IDs		B4DDM3 B4DQ37 B4DTB8 Q15036	A0A590UJ98 Q14114
PDB IDs		3FOG 3LUI 4GXB 4TKN	3A7Q 5B4X 5B4Y
Enriched GO Terms of Interacting Partners?
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