LRP8 and ANAPC10

Number of citations of the paper that reports this interaction (PubMedID 10827173)
122

Data Source:
BioGRID (two hybrid)

		LRP8	ANAPC10
Description		LDL receptor related protein 8	anaphase promoting complex subunit 10
Image
GO Annotations	Cellular Component	Extracellular Region Microtubule Associated Complex Plasma Membrane Caveola Postsynaptic Density Membrane Integral Component Of Membrane Axon Dendrite Neuronal Cell Body Receptor Complex	Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Transmembrane Signaling Receptor Activity Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding High-density Lipoprotein Particle Binding Kinesin Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Cargo Receptor Activity Reelin Receptor Activity
	Biological Process	Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Endocytosis Signal Transduction Cytokine-mediated Signaling Pathway Ammon Gyrus Development Cerebral Cortex Development Positive Regulation Of CREB Transcription Factor Activity Reelin-mediated Signaling Pathway Response To Drug Regulation Of Apoptotic Process Regulation Of Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Modulation Of Chemical Synaptic Transmission Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cholesterol Positive Regulation Of Dendrite Development	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Anaphase-promoting Complex-dependent Catabolic Process Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Platelet sensitization by LDL Retinoid metabolism and transport	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index (alcohol intake interaction) ( 23192594) Cerebrospinal fluid AB1-42 levels ( 28247064) General risk tolerance (MTAG) ( 30643258) Number of sexual partners ( 30643258) Type 2 diabetes nephropathy ( 30566433) Urinary metabolite levels in chronic kidney disease ( 31959995)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Height ( 25282103 25429064 31562340) Hip circumference ( 25673412) Mean corpuscular hemoglobin concentration ( 27863252) Mean corpuscular volume ( 27863252) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		21 interacting genes: ANAPC10 APBA2 APOE APOH CLU DAB1 DAB2 DLG4 GIPC1 GRIN1 ITGB1BP1 LRPAP1 MAPK8IP1 MAPK8IP2 MDK MYLIP NOS1AP RELN SCN3A SNX17 SYNJ2BP	15 interacting genes: ANAPC11 ANAPC7 CDC16 CDC20 CDC23 CDC27 FZR1 LIG4 LRP1 LRP2 LRP8 MAPK8IP2 SMAD2 SMAD3 TSC22D2
Entrez ID		7804	10393
HPRD ID		04002	16488
Ensembl ID		ENSG00000157193	ENSG00000164162
Uniprot IDs		A0A590UJ98 Q14114	Q9UM13
PDB IDs		3A7Q 5B4X 5B4Y	1JHJ 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H
Enriched GO Terms of Interacting Partners?
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