ADGRE5 and XRN1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)

		ADGRE5	XRN1
Description		adhesion G protein-coupled receptor E5	5'-3' exoribonuclease 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Membrane Secretory Granule Membrane Extracellular Exosome	P-body Nucleus Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcium Ion Binding Protein Binding	G-quadruplex RNA Binding RNA Binding 5'-3' Exoribonuclease Activity Protein Binding G-quadruplex DNA Binding Telomerase RNA Binding
	Biological Process	Inflammatory Response Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Neutrophil Degranulation	Nuclear-transcribed MRNA Catabolic Process RRNA Catabolic Process Negative Regulation Of Translation Negative Regulation Of Telomere Maintenance Via Telomerase Response To Testosterone Regulation Of MRNA Stability Nuclear MRNA Surveillance Histone MRNA Catabolic Process Cellular Response To Cycloheximide RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Response To Puromycin
Pathways		Class B/2 (Secretin family receptors) Neutrophil degranulation	mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Drugs
Diseases
GWAS		Blood protein levels ( 28240269)	Birth weight ( 31043758) Heel bone mineral density ( 30598549) Mosquito bite size ( 28199695) Waist-hip ratio ( 28552196)
Interacting Genes		4 interacting genes: CD55 GCC1 HNRNPD XRN1	63 interacting genes: ADGRE5 ALDOA ANGPTL6 AP1G2 ATP5MC2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CENPBD1 CHD4 CTSB CTSH DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 FBXO7 GLMP HEATR1 HERC2P4 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MFSD5 MTCH2 MTREX NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF187 SDHB SKIV2L SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPL ZFP36
Entrez ID		976	54464
HPRD ID		03130	10470
Ensembl ID		ENSG00000123146	ENSG00000114127
Uniprot IDs		P48960	Q8IZH2
PDB IDs		2BOU
Enriched GO Terms of Interacting Partners?
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