XRN1 and LEPR

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)

		XRN1	LEPR
Description		5'-3' exoribonuclease 1	leptin receptor
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body Synapse	Extracellular Region External Side Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Receptor Complex
	Molecular Function	G-quadruplex RNA Binding RNA Binding 5'-3' Exoribonuclease Activity Protein Binding G-quadruplex DNA Binding Telomerase RNA Binding	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Peptide Hormone Binding Cytokine Binding Leptin Receptor Activity Identical Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process RRNA Catabolic Process Negative Regulation Of Translation Negative Regulation Of Telomere Maintenance Via Telomerase Response To Testosterone Regulation Of MRNA Stability Nuclear MRNA Surveillance Histone MRNA Catabolic Process Cellular Response To Cycloheximide RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Response To Puromycin	Angiogenesis Positive Regulation Of Protein Phosphorylation Glycogen Metabolic Process Energy Reserve Metabolic Process Phagocytosis Cell Surface Receptor Signaling Pathway Multicellular Organism Development Cholesterol Metabolic Process Negative Regulation Of Autophagy Glial Cell Proliferation Sexual Reproduction T Cell Differentiation Leptin-mediated Signaling Pathway Glucose Homeostasis Cellular Response To Leptin Stimulus Response To Leptin Negative Regulation Of Gluconeogenesis Regulation Of Bone Remodeling Regulation Of Transport Negative Regulation Of Hydrolase Activity Regulation Of Feeding Behavior Energy Homeostasis Bone Growth Positive Regulation Of Cold-induced Thermogenesis
Pathways		mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Drugs			Leptin Metreleptin
Diseases
GWAS		Birth weight ( 31043758) Heel bone mineral density ( 30598549) Mosquito bite size ( 28199695) Waist-hip ratio ( 28552196)	Age at voice drop ( 27182965) Blood protein levels ( 30072576 29875488 28240269) BMI at 1 year old ( 31575865) BMI at 1.5 years old ( 31575865) BMI at 3 months old ( 31575865) BMI at 6 months old ( 31575865) BMI at 8 months old ( 31575865) BMI at adiposity peak ( 31840077) C-reactive protein ( 19567438 18439548 23844046 22939635) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Fasting plasma glucose (childhood) ( 25223902) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Granulocyte count ( 27863252) Hip circumference ( 28552196) Lymphocyte percentage of white cells ( 27863252) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Menarche (age at onset) ( 25231870) Metabolic traits ( 19060910) Molybdenum levels ( 26025379) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Obesity (early onset extreme) ( 23563609) Soluble leptin receptor levels ( 20167575) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)
Interacting Genes		63 interacting genes: ADGRE5 ALDOA ANGPTL6 AP1G2 ATP5MC2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CENPBD1 CHD4 CTSB CTSH DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 FBXO7 GLMP HEATR1 HERC2P4 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MFSD5 MTCH2 MTREX NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF187 SDHB SKIV2L SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPL ZFP36	16 interacting genes: APOD CLU CSNK2B DGKZ JAK2 LEP PIN1 PTPN11 RNF41 SNX1 SNX2 SNX4 SNX6 SOCS3 STAT3 XRN1
Entrez ID		54464	3953
HPRD ID		10470	03001
Ensembl ID		ENSG00000114127	ENSG00000116678
Uniprot IDs		Q8IZH2	P48357 Q4G138
PDB IDs			3V6O 6E2P
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?