XRN1 and SRRM2

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)

		XRN1	SRRM2
Description		5'-3' exoribonuclease 1	serine/arginine repetitive matrix 2
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body Synapse	Nucleus Nucleoplasm Cajal Body Nuclear Speck U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	G-quadruplex RNA Binding RNA Binding 5'-3' Exoribonuclease Activity Protein Binding G-quadruplex DNA Binding Telomerase RNA Binding	RNA Binding MRNA Binding Protein N-terminus Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process RRNA Catabolic Process Negative Regulation Of Translation Negative Regulation Of Telomere Maintenance Via Telomerase Response To Testosterone Regulation Of MRNA Stability Nuclear MRNA Surveillance Histone MRNA Catabolic Process Cellular Response To Cycloheximide RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Response To Puromycin	MRNA Splicing, Via Spliceosome
Pathways		mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Birth weight ( 31043758) Heel bone mineral density ( 30598549) Mosquito bite size ( 28199695) Waist-hip ratio ( 28552196)	Height ( 31562340)
Interacting Genes		63 interacting genes: ADGRE5 ALDOA ANGPTL6 AP1G2 ATP5MC2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CENPBD1 CHD4 CTSB CTSH DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 FBXO7 GLMP HEATR1 HERC2P4 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MFSD5 MTCH2 MTREX NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF187 SDHB SKIV2L SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPL ZFP36	14 interacting genes: APP CLK1 CSNK2A1 PIN1 PNN PRPF6 SNIP1 SRPK2 SRRM1 SRSF4 TTC14 XRN1 YWHAB YWHAG
Entrez ID		54464	23524
HPRD ID		10470	06913
Ensembl ID		ENSG00000114127	ENSG00000167978
Uniprot IDs		Q8IZH2	A0A140VK53 Q9UQ35
PDB IDs			5MQF 5XJC 5YZG 5Z56 5Z57 6FF4 6FF7 6ICZ 6QDV
Enriched GO Terms of Interacting Partners?
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