CD81 and RNF128

Number of citations of the paper that reports this interaction (PubMedID 18713730)
25

Data Source:
HPRD (in vivo)

		CD81	RNF128
Description		CD81 molecule	ring finger protein 128
Image
GO Annotations	Cellular Component	Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Membrane Integral Component Of Membrane Basolateral Plasma Membrane Vesicle Extracellular Exosome Tetraspanin-enriched Microdomain	Late Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Virus Receptor Activity Integrin Binding Protein Binding Cholesterol Binding MHC Class II Protein Complex Binding MHC Class II Protein Binding Transferrin Receptor Binding	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Activation Of MAPK Activity Immunological Synapse Formation Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Inflammatory Response To Antigenic Stimulus Protein Localization Positive Regulation Of Cell Proliferation Myoblast Fusion Involved In Skeletal Muscle Regeneration Regulation Of Complement Activation Positive Regulation Of B Cell Proliferation Receptor Internalization Regulation Of Protein Stability Macrophage Fusion CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of 1-phosphatidylinositol 4-kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Protein Localization To Lysosome Positive Regulation Of Protein Exit From Endoplasmic Reticulum Cellular Response To Low-density Lipoprotein Particle Stimulus Protein Localization To Plasma Membrane Osteoclast Fusion Positive Regulation Of Receptor Clustering Positive Regulation Of Protein Catabolic Process In The Vacuole Regulation Of Macrophage Migration Positive Regulation Of Adaptive Immune Memory Response Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Regulation Of Protein Stability Negative Regulation Of Cytokine Biosynthetic Process Protein Localization To Lysosome Positive Regulation Of Protein Catabolic Process In The Vacuole
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Regulation of Complement cascade	Ub-specific processing proteases Ovarian tumor domain proteases
Drugs
Diseases
GWAS			Alcoholic chronic pancreatitis ( 28754779) Creatinine levels ( 31015462) Estimated glomerular filtration rate ( 31015462)
Interacting Genes		23 interacting genes: ADRB2 CD19 CD9 CSNK2B DLG5 GLP1R HNRNPD IFITM1 IGSF8 INO80B ITGA4 JAK3 KIT LMNA MYOC PTGFRN RBBP6 RNF128 SHC1 SIRPA TSPAN4 VKORC1 ZBTB16	14 interacting genes: APPBP2 CD151 CD40LG CD81 CEP76 OTUB1 TBK1 TP53 UBE2D1 UBE2E1 UBE2H UBE2I UBE2N UBE2T
Entrez ID		975	79589
HPRD ID		08924	02340
Ensembl ID		ENSG00000110651	ENSG00000133135
Uniprot IDs		A0A024RCB7 E9PJK1 P60033	Q8TEB7
PDB IDs		1G8Q 1IV5 2AVZ 3X0E 5DFV 5DFW 5M2C 5M33 5M3D 5M3T 5M4R 5TCX 6EJG 6EJM 6EK2	3ICU
Enriched GO Terms of Interacting Partners?
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