CD79B and CD3E

Number of citations of the paper that reports this interaction (PubMedID 7541024)
1

Data Source:
HPRD (in vitro, in vivo)

		CD79B	CD3E
Description		CD79b molecule	CD3e molecule
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane B Cell Receptor Complex Extracellular Exosome	Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex Dendritic Spine Cell Body
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Receptor Signaling Complex Scaffold Activity T Cell Receptor Binding Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	Adaptive Immune Response Immune Response Signal Transduction Response To Bacterium B Cell Differentiation B Cell Receptor Signaling Pathway	Positive Regulation Of Cell-matrix Adhesion Adaptive Immune Response Positive Regulation Of T Cell Anergy Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Complex Assembly G Protein-coupled Receptor Signaling Pathway Response To Nutrient Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Dendrite Development Cerebellum Development T Cell Differentiation T Cell Costimulation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of Apoptotic Process Positive Thymic T Cell Selection Negative Thymic T Cell Selection Positive Regulation Of Interleukin-2 Biosynthetic Process Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Protein-containing Complex Assembly Apoptotic Signaling Pathway
Pathways		CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling
Drugs			Muromonab
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8	T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Height ( 25282103)	Lung cancer in ever smokers ( 28604730) Pulse pressure ( 27841878)
Interacting Genes		14 interacting genes: BLK CD19 CD3E CD5 CD79A FYN LCK LYN PDZD11 PTK2 PTPN6 SGTA SYK ZAP70	20 interacting genes: CD3D CD3EAP CD3G CD79B CSK EPS8L1 LCK NCK1 NCK2 NCL PIK3R1 PTPN22 SHC1 SNTA1 SYK TOP2B TRAT1 TRB UNC119 ZAP70
Entrez ID		974	916
HPRD ID		00922	08923
Ensembl ID		ENSG00000007312	ENSG00000198851
Uniprot IDs		P40259	P07766
PDB IDs		3KG5	1A81 1SY6 1XIW 2ROL 6JXR
Enriched GO Terms of Interacting Partners?
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