DCAF1 and TET2

Number of citations of the paper that reports this interaction (PubMedID 25557551)
33

Data Source:
BioGRID (pull down)

		DCAF1	TET2
Description		DDB1 and CUL4 associated factor 1	tet methylcytosine dioxygenase 2
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm COP9 Signalosome Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus
	Molecular Function	Protein Binding ATP Binding Estrogen Receptor Binding Histone Kinase Activity (H2A-T120 Specific)	DNA Binding Iron Ion Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Methylcytosine Dioxygenase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Viral Process Protein Ubiquitination B Cell Differentiation V(D)J Recombination Cell Competition In A Multicellular Organism Histone H2A-T120 Phosphorylation	5-methylcytosine Catabolic Process Protein O-linked Glycosylation Cell Cycle Response To Organic Cyclic Compound Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Oxidative Demethylation DNA Demethylation Histone H3-K4 Trimethylation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	TET1,2,3 and TDG demethylate DNA
Drugs
Diseases
GWAS			Adventurousness ( 30643258) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 23535729) Chronic obstructive pulmonary disease ( 28166215 30804561) Coffee consumption ( 31046077) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal or endometrial cancer ( 26621817) Estimated glomerular filtration rate ( 31451708) Extremely high intelligence ( 29520040) FEV1 ( 30804560) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Height ( 20881960 25429064 31562340) Household income (MTAG) ( 31844048) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphocyte counts ( 29403010 27863252) Lymphocyte percentage of white cells ( 27863252) Melanoma ( 24980573) Molybdenum levels ( 26025379) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of white cells ( 27863252) Offspring birth weight ( 31043758) Peak expiratory flow ( 30804560) Plateletcrit ( 27863252) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 25939597 19767753) Pulmonary function ( 21946350) Regular attendance at a religious group ( 29970889) Self-reported risk-taking behaviour ( 30271922) Tonsillectomy ( 27182965 28928442) Western dietary pattern ( 28644415)
Interacting Genes		20 interacting genes: ATM ATR CCP110 EXO1 FOXM1 H3-3A H3-4 H3C1 HLTF IMPDH2 KATNA1 NF2 PRKDC PYGO2 RAG1 RBX1 SAMHD1 TET2 TP53 UBE2D2	2 interacting genes: DCAF1 TBC1D4
Entrez ID		9730	54790
HPRD ID		11674	07876
Ensembl ID		ENSG00000145041	ENSG00000168769
Uniprot IDs		Q9Y4B6	A0A024RDF7 A0A158SIU0 Q6N021
PDB IDs		3WA0 4CC9 4P7I 4PXW 4Z8L 5AJA 5JK7 6N45	4NM6 5D9Y 5DEU
Enriched GO Terms of Interacting Partners?
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