ADAMTSL2 and FBLN1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ADAMTSL2	FBLN1
Description		ADAMTS like 2	fibulin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Matrix	Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber
	Molecular Function	Protein Binding Peptidase Activity Microfibril Binding	Fibronectin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein C-terminus Binding Peptidase Activator Activity Identical Protein Binding Protein-containing Complex Binding Fibrinogen Binding
	Biological Process	Proteolysis Extracellular Matrix Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Lobar Bronchus Epithelium Development	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Embryo Implantation Positive Regulation Of Peptidase Activity Viral Process Extracellular Matrix Organization Negative Regulation Of ERK1 And ERK2 Cascade Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Cell Motility Negative Regulation Of Stem Cell Proliferation
Pathways		Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins	Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases		Geleophysic dysplasia	Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses
GWAS			Blood protein levels ( 30072576) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Paneth cell defects in Crohn's disease ( 28352666) QT interval ( 29213071) Red blood cell count ( 27863252) Temperament (bipolar disorder) ( 22365631)
Interacting Genes		1 interacting genes: FBLN1	39 interacting genes: ACAN ADAMTSL2 ADAMTSL4 APOA1 APP ATN1 BHLHE40 CACNA1A CCN2 CCN3 DDIAS ECM1 EDC4 ELN FGB FN1 GFI1B HBEGF HSPG2 ITGB1 LTBP4 MCPH1 MFAP5 MOB4 NEDD1 NID1 NLGN3 NOTCH3 PLSCR1 SKIL SMAD3 SMAD4 TAF9 TANK TCF7L2 TDGF1 TLE5 VCAN YWHAQ
Entrez ID		9719	2192
HPRD ID		11096	00629
Ensembl ID		ENSG00000197859	ENSG00000077942
Uniprot IDs		B1B0D4 Q86TH1	P23142 Q8NBH6
PDB IDs
Enriched GO Terms of Interacting Partners?
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