CEP135 and SPINK2

		CEP135	SPINK2
Description		centrosomal protein 135	serine peptidase inhibitor Kazal type 2
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GO Annotations	Cellular Component	Centrosome Centriole Cytosol	Acrosomal Vesicle Extracellular Region
	Molecular Function	Protein Binding Protein C-terminus Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Centriole-centriole Cohesion Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Non-motile Cilium Assembly Positive Regulation Of Establishment Of Protein Localization	Acrosome Assembly Spermatid Development Negative Regulation Of Serine-type Endopeptidase Activity
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Daytime sleep phenotypes ( 27126917) Femoral neck bone mineral density ( 30172743) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Aggressiveness in attention deficit hyperactivity disorder ( 27021288) Blood protein levels ( 30072576 29875488) Migraine ( 27322543) Post bronchodilator FEV1/FVC ratio ( 26634245) Stroke ( 26089329) Systemic sclerosis ( 30247649)
Interacting Genes		7 interacting genes: CLOCK DCUN1D4 PIBF1 REST SMAD9 SPINK2 USP46	6 interacting genes: ADAMTSL4 CEP135 KRTAP10-3 KRTAP5-9 MAPK8IP2 NOTCH2NLA
Entrez ID		9662	6691
HPRD ID		11097	10422
Ensembl ID		ENSG00000174799	ENSG00000128040
Uniprot IDs		Q66GS9	A0A024RD95 A0A087WTA9 D6RC51 D6RI10 P20155
PDB IDs		5FCN 5NG4	2JXD 6KBR
Enriched GO Terms of Interacting Partners?
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