CEP135 and USP46

		CEP135	USP46
Description		centrosomal protein 135	ubiquitin specific peptidase 46
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GO Annotations	Cellular Component	Centrosome Centriole Cytosol	Glutamatergic Synapse
	Molecular Function	Protein Binding Protein C-terminus Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Metal Ion Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Centriole-centriole Cohesion Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Non-motile Cilium Assembly Positive Regulation Of Establishment Of Protein Localization	Behavioral Fear Response Ubiquitin-dependent Protein Catabolic Process Adult Feeding Behavior Protein Deubiquitination Regulation Of Synaptic Transmission, GABAergic Behavioral Response To Ethanol Righting Reflex Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Daytime sleep phenotypes ( 27126917) Femoral neck bone mineral density ( 30172743) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Biochemical measures ( 19260141) Height ( 31562340) Platelet count ( 29403010) Type 2 diabetes ( 30297969)
Interacting Genes		7 interacting genes: CLOCK DCUN1D4 PIBF1 REST SMAD9 SPINK2 USP46	7 interacting genes: CEP135 GRIA1 H2AC20 H2BC21 MAPK8IP2 UBA52 UBC
Entrez ID		9662	64854
HPRD ID		11097	07507
Ensembl ID		ENSG00000174799	ENSG00000109189
Uniprot IDs		Q66GS9	P62068
PDB IDs		5FCN 5NG4	5CVM 5CVN 5CVO 5L8H 6JLQ
Enriched GO Terms of Interacting Partners?
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