SH3PXD2A and SVIL

Number of citations of the paper that reports this interaction (PubMedID 20309963)
26

Data Source:
BioGRID (two hybrid)

		SH3PXD2A	SVIL
Description		SH3 and PX domains 2A	supervillin
Image
GO Annotations	Cellular Component	Podosome Cytosol Cell Junction Cell Projection	Podosome Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Midbody Cleavage Furrow Microtubule Minus-end Costamere Invadopodium
	Molecular Function	Protease Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-5-phosphate Binding Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding	Protein Binding Actin Filament Binding
	Biological Process	In Utero Embryonic Development Superoxide Metabolic Process Extracellular Matrix Organization Positive Regulation Of Catalytic Activity Osteoclast Fusion	Cytoskeleton Organization Skeletal Muscle Tissue Development Positive Regulation Of Cytokinesis
Pathways		Invadopodia formation
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818 28416822 29290336 29892015) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Cutaneous malignant melanoma ( 26237428) Diisocyanate-induced asthma ( 25918132) Intraocular pressure ( 29617998) Ischemic stroke ( 29531354) Ischemic stroke (small-vessel) ( 29531354) Manganese levels ( 26025379) PR interval ( 30046033) Rheumatoid arthritis ( 30891314) Stroke ( 29531354) Waist circumference adjusted for body mass index ( 28552196) White matter hyperintensity burden ( 25663218)	Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Bone fracture in osteoporosis ( 28580392) Estimated glomerular filtration rate ( 31152163) Lung function (FEV1/FVC) ( 28166213) Metabolite levels ( 23823483) Neurofibrillary tangles ( 25188341) Normalized brain volume ( 19010793) Platelet thrombus formation ( 22550155)
Interacting Genes		7 interacting genes: ADAM15 AFAP1L2 FASLG KHDRBS1 PAK2 SRC SVIL	36 interacting genes: AR ATRX BUB1 CENPF DYNLT1 ESR1 FLNA HAX1 HMMR HSP90AA1 ITGB3BP KIF14 KIF22 KIFC3 KMT2A KRT18 LMNA LMNB2 LUC7L2 MIF4GD MPHOSPH9 MRTFB NME2 NR3C1 ODF2 P2RX7 PAN3 PCNX3 PPARG SH3PXD2A STARD9 TGFB1I1 TNFAIP1 TRIP6 UXT YWHAG
Entrez ID		9644	6840
HPRD ID		10228	04992
Ensembl ID		ENSG00000107957	ENSG00000197321
Uniprot IDs		B3KPL1 Q5TCZ1	O95425 Q569J5
PDB IDs		2DNU 2EGA 2EGC 2EKH	2K6M 2K6N
Enriched GO Terms of Interacting Partners?
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