SVIL and DYNLT1

Number of citations of the paper that reports this interaction (PubMedID 16880273)
29

Data Source:
BioGRID (pull down)

		SVIL	DYNLT1
Description		supervillin	dynein light chain Tctex-type 1
Image
GO Annotations	Cellular Component	Podosome Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Midbody Cleavage Furrow Microtubule Minus-end Costamere Invadopodium	Extracellular Region Cell Mitochondrion Golgi Apparatus Spindle Cytoplasmic Dynein Complex Cytoplasmic Microtubule Lamellipodium Secretory Granule Lumen Neuronal Cell Body Host Cell Axonal Growth Cone Secretory Vesicle Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Actin Filament Binding	Motor Activity Protein Binding Protein C-terminus Binding Identical Protein Binding
	Biological Process	Cytoskeleton Organization Skeletal Muscle Tissue Development Positive Regulation Of Cytokinesis	Establishment Of Mitotic Spindle Orientation Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development Dendrite Development Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Rac Protein Signal Transduction Negative Regulation Of Mitochondrial Membrane Permeability Regulation Of GTPase Activity Neutrophil Degranulation Viral Entry Into Host Cell Neuron Projection Morphogenesis Negative Regulation Of Neurogenesis Cell Division Regulation Of Cytoskeleton Organization Negative Regulation Of Cell Death Axon Development Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Bone fracture in osteoporosis ( 28580392) Estimated glomerular filtration rate ( 31152163) Lung function (FEV1/FVC) ( 28166213) Metabolite levels ( 23823483) Neurofibrillary tangles ( 25188341) Normalized brain volume ( 19010793) Platelet thrombus formation ( 22550155)
Interacting Genes		36 interacting genes: AR ATRX BUB1 CENPF DYNLT1 ESR1 FLNA HAX1 HMMR HSP90AA1 ITGB3BP KIF14 KIF22 KIFC3 KMT2A KRT18 LMNA LMNB2 LUC7L2 MIF4GD MPHOSPH9 MRTFB NME2 NR3C1 ODF2 P2RX7 PAN3 PCNX3 PPARG SH3PXD2A STARD9 TGFB1I1 TNFAIP1 TRIP6 UXT YWHAG	26 interacting genes: APP BAG3 BMPR2 DDX54 DHX33 DOC2A DOC2B DVL1 DVL2 DYNC1I1 FXR2 HAVCR1 HSPB9 ILF2 KIF2A NUP153 NUP62 PVR RAD21 RBM14 SVIL TROAP TUBA3C TXN VDAC1 XRN2
Entrez ID		6840	6993
HPRD ID		04992	15987
Ensembl ID		ENSG00000197321	ENSG00000146425
Uniprot IDs		O95425 Q569J5	P63172
PDB IDs		2K6M 2K6N	5JPW
Enriched GO Terms of Interacting Partners?
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