RIN1 and ANKS1B

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		RIN1	ANKS1B
Description		Ras and Rab interactor 1	ankyrin repeat and sterile alpha motif domain containing 1B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Dendrite Neuronal Cell Body	Cytosol Plasma Membrane Postsynaptic Density Cajal Body Cell Junction Dendritic Spine Intracellular Membrane-bounded Organelle
	Molecular Function	GTPase Activator Activity Protein Binding Ras GTPase Binding	Ephrin Receptor Binding
	Biological Process	Endocytosis Signal Transduction Memory Associative Learning Negative Regulation Of Synaptic Plasticity Positive Regulation Of GTPase Activity	Regulation Of Synaptic Plasticity By Receptor Localization To Synapse
Pathways		RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972 31043756)	Alcohol dependence or heroin dependence or methamphetamine dependence ( 31462767) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat percentage ( 31752434) Body mass index ( 20966902) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Electrodermal activity ( 25387706) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Obesity-related traits ( 23251661) Peak cortisol response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Response to antipsychotic treatment ( 19721433) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Waist circumference ( 20966902)
Interacting Genes		19 interacting genes: ABL1 ABL2 AFDN ANKS1B CALCOCO2 EGFR ERBB2 ERBB3 HRAS KRTAP13-1 LZTS2 MTDH RAB5A RAB5B RALGDS RRAS2 YWHAB YWHAE YWHAZ	9 interacting genes: APP EGFR ERBB2 ERBB4 HTR2A LRP1 LRP2 RIN1 UBC
Entrez ID		9610	56899
HPRD ID		05813	07426
Ensembl ID		ENSG00000174791	ENSG00000185046
Uniprot IDs		A0A0S2Z4U0 Q13671	B1VKB5 B7Z9I9 Q6V0K8 Q7Z6G8
PDB IDs			2EAM 2KE7 2KIV 2M38
Enriched GO Terms of Interacting Partners?
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