PRDX6 and SFTPA1

Number of citations of the paper that reports this interaction (PubMedID 16330552)
34

Data Source:
BioGRID (pull down)

		PRDX6	SFTPA1
Description		peroxiredoxin 6	surfactant protein A1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Nucleus Cytoplasm Mitochondrion Cytosol Membrane Azurophil Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle
	Molecular Function	Glutathione Peroxidase Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Cadherin Binding Calcium-independent Phospholipase A2 Activity Peroxiredoxin Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	Lipid Transporter Activity Protein Binding Monosaccharide Binding
	Biological Process	Response To Oxidative Stress Cellular Response To Oxidative Stress Hydrogen Peroxide Catabolic Process Neutrophil Degranulation Cell Redox Homeostasis Glycerophospholipid Catabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Oxidation-reduction Process Cellular Oxidant Detoxification	Toll-like Receptor Signaling Pathway Lipid Transport Respiratory Gaseous Exchange Opsonization Developmental Process Cellular Protein Metabolic Process
Pathways		Detoxification of Reactive Oxygen Species Neutrophil degranulation	Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor TLR1:TLR2 Cascade Signal regulatory protein family interactions Surfactant metabolism Regulation of TLR by endogenous ligand Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
Drugs		Isopropyl Alcohol 2-(N-Morpholino)-Ethanesulfonic Acid Copper	2-(N-Morpholino)-Ethanesulfonic Acid
Diseases
GWAS		Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Blood protein levels ( 30072576) Systemic lupus erythematosus ( 26663301) Systemic sclerosis ( 31672989)
Interacting Genes		19 interacting genes: CASP10 CASP8 GPX4 GSTP1 HNF4G MAPK1 NCF2 NR4A1 ORM2 PAXIP1 PPARD RARA SFTPA1 STH SUMO4 TERF1 TERF2IP UCHL5 YWHAE	2 interacting genes: DMBT1 PRDX6
Entrez ID		9588	653509
HPRD ID		03817	19256
Ensembl ID		ENSG00000117592	ENSG00000122852
Uniprot IDs		P30041 V9HWC7	A0A024QZP2 B4DNP6 Q8IWL2
PDB IDs		1PRX 5B6M 5B6N
Enriched GO Terms of Interacting Partners?
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