AKAP9 and WAC

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		AKAP9	WAC
Description		A-kinase anchoring protein 9	WW domain containing adaptor with coiled-coil
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Golgi Stack Cis-Golgi Network Centrosome Cytosol Cytoskeleton Voltage-gated Potassium Channel Complex Neuronal Cell Body Intracellular Membrane-bounded Organelle Dendritic Branch Synaptic Membrane Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck
	Molecular Function	DNA Binding Signaling Receptor Binding Protein Binding Potassium Channel Regulator Activity Protein Kinase A Regulatory Subunit Binding Ion Channel Binding Molecular Adaptor Activity	RNA Polymerase II Complex Binding Chromatin Binding Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Nucleation Signal Transduction Negative Regulation Of Adenylate Cyclase Activity Chemical Synaptic Transmission Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Response To Electrical Stimulus Maintenance Of Centrosome Location Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Cellular Response To CAMP Regulation Of Heart Rate By Cardiac Conduction Ciliary Basal Body-plasma Membrane Docking Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Postsynaptic Neurotransmitter Receptor Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Golgi Organization	Cellular Response To DNA Damage Stimulus Histone Monoubiquitination Positive Regulation Of Macroautophagy Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process G1 DNA Damage Checkpoint Positive Regulation Of Transcription, DNA-templated Histone H2B Conserved C-terminal Lysine Ubiquitination
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Phase 3 - rapid repolarisation Phase 2 - plateau phase Anchoring of the basal body to the plasma membrane Signaling by BRAF and RAF fusions AURKA Activation by TPX2	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Breast cancer ( 29059683) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Hippocampal volume in Alzheimer's disease dementia ( 29274321)	Diastolic blood pressure ( 30224653) Intraocular pressure ( 29617998) Multiple myeloma ( 27363682)
Interacting Genes		67 interacting genes: ASB4 BLZF1 C1orf94 CALM1 CALM2 CALM3 CASK CCP110 CDC5L CEP55 CLIC1 CSNK1D CSNK1E CTBP1 DVL2 FMR1 FNBP1 FXR2 GATAD1 GPC4 GRIN1 GTSE1 HNRNPM IKZF3 KCNQ1 KDM1A KIF19 KLC4 MAGEA6 MAGED1 MED1 MYO5A NDEL1 PARD6G PCM1 PCNT PKN1 PKP2 PPP1CA PPP2R1B PPP2R3A PRC1 PRDM14 PRKAR2A PRKAR2B PRKCE RBM10 RBM14 RPA2 SAMD3 SF3B2 SGCE SLAIN1 SSX2 SUV39H2 TACC3 TDP2 THAP1 TNIK TRIP10 TSG101 TSNAX TUBGCP3 USHBP1 USO1 WAC YWHAE	20 interacting genes: AKAP9 APP CRKL DYDC1 KLC3 KRT15 LNX1 MOBP MTUS2 NDE1 NFE2L2 POLR2A SYTL5 TRAF1 TRAF3IP1 TRAF3IP3 UBQLN4 VCP VCPIP1 ZDHHC17
Entrez ID		10142	51322
HPRD ID		04921	18291
Ensembl ID		ENSG00000127914	ENSG00000095787
Uniprot IDs		Q5GIA7 Q6PJH3 Q99996	Q9BTA9
PDB IDs
Enriched GO Terms of Interacting Partners?
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