CD36 and CD9

Number of citations of the paper that reports this interaction (PubMedID 11238109)
33

Data Source:
HPRD (in vivo)

		CD36	CD9
Description		CD36 molecule	CD9 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cell Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Platelet Alpha Granule Membrane Brush Border Membrane Specific Granule Membrane Receptor Complex Membrane Raft Phagocytic Vesicle Cell Periphery	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Platelet Alpha Granule Membrane Protein-containing Complex Extracellular Exosome Extracellular Vesicle
	Molecular Function	Amyloid-beta Binding Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Protein Binding High-density Lipoprotein Particle Binding Lipid Binding Low-density Lipoprotein Particle Binding Toll-like Receptor Binding Protein-containing Complex Binding Transforming Growth Factor Beta Binding Thrombospondin Receptor Activity Lipoteichoic Acid Receptor Activity Lipoprotein Particle Binding Oxidised Low-density Lipoprotein Particle Receptor Activity	Integrin Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell-matrix Adhesion Toll-like Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Production Of Molecular Mediator Involved In Inflammatory Response Platelet Degranulation MyD88-dependent Toll-like Receptor Signaling Pathway Lipid Metabolic Process Fatty Acid Metabolic Process Receptor-mediated Endocytosis Phagocytosis, Recognition Phagocytosis, Engulfment Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Nitric Oxide Mediated Signal Transduction Blood Coagulation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Storage Positive Regulation Of Cell Death Regulation Of Lipid Metabolic Process Cytokine-mediated Signaling Pathway Lipid Storage CGMP-mediated Signaling Positive Regulation Of Blood Coagulation Intestinal Cholesterol Absorption Cholesterol Transport Receptor Internalization Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Lipid Regulation Of Toll-like Receptor Signaling Pathway Triglyceride Transport Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance Response To Stilbenoid Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Protein Import Into Nucleus Lipoprotein Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Complex Assembly Apoptotic Cell Clearance Neutrophil Degranulation Long-chain Fatty Acid Import Positive Regulation Of Nitric Oxide Biosynthetic Process Interleukin-1 Beta Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-positive Bacterium Intestinal Absorption Sensory Perception Of Taste Positive Regulation Of NF-kappaB Transcription Factor Activity Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of ERK1 And ERK2 Cascade Cholesterol Import Response To Fatty Acid Response To Linoleic Acid Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Hydroperoxide Cellular Response To Diacyl Bacterial Lipopeptide Energy Homeostasis Regulation Of Action Potential Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Oxidised Low-density Lipoprotein Particle Clearance Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Amyloid-beta Amyloid Fibril Formation Regulation Of Removal Of Superoxide Radicals Positive Regulation Of Blood Microparticle Formation	Platelet Degranulation Cell Adhesion Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Brain Development Negative Regulation Of Cell Proliferation Response To Water Deprivation Oligodendrocyte Development Myoblast Fusion Involved In Skeletal Muscle Regeneration Platelet Activation Paranodal Junction Assembly Receptor Internalization Sperm-egg Recognition Negative Regulation Of Cellular Component Movement Cellular Response To Low-density Lipoprotein Particle Stimulus Negative Regulation Of Platelet Aggregation Regulation Of Macrophage Migration
Pathways		Platelet degranulation Cross-presentation of particulate exogenous antigens (phagosomes) ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade PPARA activates gene expression Scavenging by Class B Receptors Scavenging by Class B Receptors Transcriptional regulation of white adipocyte differentiation Intracellular metabolism of fatty acids regulates insulin secretion MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	Platelet degranulation Acrosome Reaction and Sperm:Oocyte Membrane Binding Uptake and function of diphtheria toxin
Drugs			C31G
Diseases
GWAS		Aspartate aminotransferase levels ( 29403010) Blood protein levels ( 30072576) HDL cholesterol ( 23726366 30275531) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010) Left ventricular mass ( 19454037) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 27863252) Mean platelet volume ( 27863252) Night sleep phenotypes ( 27126917) Platelet count ( 29403010 22423221 27863252) Red blood cell count ( 27863252) Red cell distribution width ( 28957414) Response to fenofibrate ( 22890011)	Colorectal cancer ( 24836286) Colorectal cancer or advanced adenoma ( 30510241) Mean platelet volume ( 22139419 27863252) Paclitaxel-induced neuropathy ( 23776197) Platelet count ( 26805783 22139419)
Interacting Genes		19 interacting genes: APOB APP CD9 CHRD COL1A1 COL1A2 FYN HSD11B1 ITGA2B ITGA6 ITGB1 ITGB3 LDLR LYN MATK SRC THBS1 VLDLR YES1	22 interacting genes: ADAM2 ADRB2 CD19 CD36 CD38 CD53 CD59 CD63 CD81 CLN8 HBEGF IGSF8 ITGA2 ITGA3 ITGA5 ITGB1 KIT PRKCA PTGFRN SERPINH1 TSPAN4 VKORC1
Entrez ID		948	928
HPRD ID		01430	00880
Ensembl ID		ENSG00000135218	ENSG00000010278
Uniprot IDs		A4D1B1 B7Z6C3 E9PLT1 P16671	A6NNI4 B4DK09 P21926
PDB IDs		5LGD
Enriched GO Terms of Interacting Partners?
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