CD36 and LYN

Number of citations of the paper that reports this interaction (PubMedID 1715582)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CD36	LYN
Description		CD36 molecule	LYN proto-oncogene, Src family tyrosine kinase
Image
GO Annotations	Cellular Component	Extracellular Space Cell Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Platelet Alpha Granule Membrane Brush Border Membrane Specific Granule Membrane Receptor Complex Membrane Raft Phagocytic Vesicle Cell Periphery	Nucleus Cytoplasm Mitochondrial Intermembrane Space Golgi Apparatus Cytosol Plasma Membrane Postsynaptic Density Mitochondrial Crista Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Integrin Alpha2-beta1 Complex Mast Cell Granule Intracellular Membrane-bounded Organelle Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Postsynaptic Specialization, Intracellular Component
	Molecular Function	Amyloid-beta Binding Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Protein Binding High-density Lipoprotein Particle Binding Lipid Binding Low-density Lipoprotein Particle Binding Toll-like Receptor Binding Protein-containing Complex Binding Transforming Growth Factor Beta Binding Thrombospondin Receptor Activity Lipoteichoic Acid Receptor Activity Lipoprotein Particle Binding Oxidised Low-density Lipoprotein Particle Receptor Activity	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding ATP Binding Kinase Activity SH3 Domain Binding Ubiquitin Protein Ligase Binding Gamma-tubulin Binding Glycosphingolipid Binding Ion Channel Binding Ephrin Receptor Binding Phosphoprotein Binding Phosphorylation-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell-matrix Adhesion Toll-like Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Production Of Molecular Mediator Involved In Inflammatory Response Platelet Degranulation MyD88-dependent Toll-like Receptor Signaling Pathway Lipid Metabolic Process Fatty Acid Metabolic Process Receptor-mediated Endocytosis Phagocytosis, Recognition Phagocytosis, Engulfment Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Nitric Oxide Mediated Signal Transduction Blood Coagulation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Storage Positive Regulation Of Cell Death Regulation Of Lipid Metabolic Process Cytokine-mediated Signaling Pathway Lipid Storage CGMP-mediated Signaling Positive Regulation Of Blood Coagulation Intestinal Cholesterol Absorption Cholesterol Transport Receptor Internalization Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Lipid Regulation Of Toll-like Receptor Signaling Pathway Triglyceride Transport Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance Response To Stilbenoid Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Protein Import Into Nucleus Lipoprotein Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Complex Assembly Apoptotic Cell Clearance Neutrophil Degranulation Long-chain Fatty Acid Import Positive Regulation Of Nitric Oxide Biosynthetic Process Interleukin-1 Beta Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-positive Bacterium Intestinal Absorption Sensory Perception Of Taste Positive Regulation Of NF-kappaB Transcription Factor Activity Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of ERK1 And ERK2 Cascade Cholesterol Import Response To Fatty Acid Response To Linoleic Acid Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Hydroperoxide Cellular Response To Diacyl Bacterial Lipopeptide Energy Homeostasis Regulation Of Action Potential Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Oxidised Low-density Lipoprotein Particle Clearance Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Amyloid-beta Amyloid Fibril Formation Regulation Of Removal Of Superoxide Radicals Positive Regulation Of Blood Microparticle Formation	B Cell Homeostasis Regulation Of Cytokine Production Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Tolerance Induction To Self Antigen Histamine Secretion By Mast Cell Platelet Degranulation Negative Regulation Of Myeloid Leukocyte Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Regulation Of B Cell Apoptotic Process Protein Phosphorylation Cellular Response To DNA Damage Stimulus Response To Sterol Depletion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Blood Coagulation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Toxic Substance Response To Hormone Response To Carbohydrate Positive Regulation Of Neuron Projection Development Oligodendrocyte Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Organic Cyclic Compound Viral Process Peptidyl-tyrosine Phosphorylation Cell Differentiation Platelet Activation Erythrocyte Differentiation Positive Regulation Of Cell Migration Negative Regulation Of B Cell Proliferation Neuron Projection Development T Cell Costimulation Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Extracellular Stimulus Response To Insulin Regulation Of Mast Cell Activation Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Heat Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Response To Amino Acid Regulation Of Mast Cell Degranulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Erythrocyte Differentiation Positive Regulation Of Ras Protein Signal Transduction Protein Autophosphorylation Ephrin Receptor Signaling Pathway Response To Axon Injury Cytokine Secretion Regulation Of Cytokine Secretion Regulation Of Inflammatory Response Negative Regulation Of Immune Response B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Cellular Component Movement Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Cellular Response To Retinoic Acid Regulation Of Monocyte Chemotaxis Regulation Of Platelet Aggregation Dendritic Cell Differentiation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Dendritic Cell Apoptotic Process
Pathways		Platelet degranulation Cross-presentation of particulate exogenous antigens (phagosomes) ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade PPARA activates gene expression Scavenging by Class B Receptors Scavenging by Class B Receptors Transcriptional regulation of white adipocyte differentiation Intracellular metabolism of fatty acids regulates insulin secretion MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	GPVI-mediated activation cascade Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Cell surface interactions at the vascular wall FCGR activation PECAM1 interactions Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling EPH-Ephrin signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation CD28 co-stimulation CTLA4 inhibitory signaling EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Dectin-2 family CD209 (DC-SIGN) signaling CD22 mediated BCR regulation Cyclin D associated events in G1 Platelet Adhesion to exposed collagen Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Growth hormone receptor signaling Growth hormone receptor signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Dasatinib 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Bosutinib Ponatinib Nintedanib
Diseases
GWAS		Aspartate aminotransferase levels ( 29403010) Blood protein levels ( 30072576) HDL cholesterol ( 23726366 30275531) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010) Left ventricular mass ( 19454037) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 27863252) Mean platelet volume ( 27863252) Night sleep phenotypes ( 27126917) Platelet count ( 29403010 22423221 27863252) Red blood cell count ( 27863252) Red cell distribution width ( 28957414) Response to fenofibrate ( 22890011)	Granulocyte count ( 27863252) Height ( 18391951) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Serum thyroid-stimulating hormone levels ( 24852370) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) White blood cell count ( 29403010 27863252)
Interacting Genes		19 interacting genes: APOB APP CD9 CHRD COL1A1 COL1A2 FYN HSD11B1 ITGA2B ITGA6 ITGB1 ITGB3 LDLR LYN MATK SRC THBS1 VLDLR YES1	117 interacting genes: ACTB ADAM15 BANK1 BCAR1 BTK CASP3 CASP7 CASP9 CBL CBLC CD19 CD22 CD36 CD72 CD79A CD79B CDK1 CDK2 CDKN1B CHST15 COASY CREBBP CRKL CSF1R CSF2RA CSF2RB CSF3R CSK CSNK2B CTLA4 DAPP1 DLG4 DOK1 DOK2 DOK3 EGFR EPOR EVL FASLG FCAR FCER1G FCGR2A FCGR2B FOLR1 GAB2 GAB3 GP6 GRIA3 HCLS1 HNRNPK IGHA1 IL1B IL2RB IL7R INPP5D ITPR1 JAK2 KHDRBS1 KIT LCP2 LIME1 MAP4K1 MAPK3 MATK MME MS4A1 MS4A2 MUC1 NDFIP2 NEDD9 NMT1 NPHS1 PAG1 PAK2 PDE4A PDE4D PECAM1 PIK3CG PILRB PLCG1 PLCG2 PPP1R15A PPP1R8 PRAM1 PRKCD PRKCQ PRKDC PTK2 PTK2B PTPN6 PTPRC RASA1 RGS16 RPL10 RPS6KB1 RPS6KB2 SH2B2 SHC1 SKAP1 SKAP2 SLC4A1 SNCA SPHK1 SPHK2 SRC STAT3 SYK TEC TNF TRAT1 TRIM28 TRIP10 TRPV4 TYK2 UBB UHRF2 UNC119
Entrez ID		948	4067
HPRD ID		01430	01301
Ensembl ID		ENSG00000135218	ENSG00000254087
Uniprot IDs		A4D1B1 B7Z6C3 E9PLT1 P16671	A8K379 P07948 Q6NUK7
PDB IDs		5LGD	1W1F 1WA7 3A4O 5XY1 6NMW
Enriched GO Terms of Interacting Partners?
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